阿片类物质对清醒大鼠血管加压素分泌的调节作用

Opioid modulation of vasopressin secretion in conscious rats.

作者信息

Yamada T, Nakao K, Itoh H, Shirakami G, Sugawara A, Saito Y, Mukoyama M, Arai H, Hosoda K, Morii N

机构信息

Second Division, Department of Medicine, Kyoto University School of Medicine, Japan.

出版信息

Clin Exp Hypertens A. 1988;10 Suppl 1:361-7. doi: 10.3109/10641968809075991.

DOI:10.3109/10641968809075991

PMID:3243002

Abstract

To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous kappa-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotine-induced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

摘要

为阐明内源性阿片肽在血管加压素（AVP）分泌调控中的作用，在清醒自由活动的大鼠中研究了源自脑啡肽原B的内源性κ激动剂亮啡肽和阿片拮抗剂纳洛酮对AVP分泌的影响。腹腔注射尼古丁可显著增加大鼠的AVP分泌。脑室注射亮啡肽预处理可显著抑制尼古丁诱导的AVP分泌。静脉注射纳洛酮可显著提高基础AVP水平以及卡巴胆碱诱导的AVP分泌。这些结果表明内源性阿片肽对大鼠的AVP分泌具有抑制作用。