Yamada T, Nakao K, Itoh H, Morii N, Shiono S, Sakamoto M, Sugawara A, Saito Y, Mukoyama M, Arai H
Department of Medicine, Kyoto University School of Medicine, Japan.
Hypertension. 1988 Feb;11(2 Pt 2):I80-3. doi: 10.1161/01.hyp.11.2_pt_2.i80.
The effects of leumorphin, a kappa-agonist derived from proenkephalin B (neoendorphin and dynorphin precursor), on vasopressin secretion were studied under basal and stimulated conditions in conscious, unrestrained rats. Intracerebroventricular injection of leumorphin (60 or 600 pmol) significantly inhibited basal vasopressin secretion. The vasopressin response induced by intracerebroventricular injection of angiotensin II (100 pmol) was significantly suppressed, in a dose-dependent fashion, by the simultaneous intracerebroventricular injection of leumorphin (6, 60, or 600 pmol). Intravenous pretreatment with naloxone (0.5 mg/kg body weight) diminished the inhibitory action of leumorphin (60 pmol) on vasopressin secretion. Moreover, naloxone (0.5 mg/kg body weight) prolonged the vasopressin secretion induced by intracerebroventricular injection of angiotensin II (100 pmol). These results indicate that leumorphin possesses a potent inhibitory effect on vasopressin secretion and that, alone or in combination with other endogenous opioid peptides, it plays an important role in the control of vasopressin secretion.
在清醒、无束缚的大鼠的基础和刺激条件下，研究了亮啡肽（一种源自脑啡肽原B（新内啡肽和强啡肽前体）的κ激动剂）对血管加压素分泌的影响。脑室内注射亮啡肽（60或600皮摩尔）可显著抑制基础血管加压素分泌。脑室内同时注射亮啡肽（6、60或600皮摩尔）以剂量依赖的方式显著抑制了脑室内注射血管紧张素II（100皮摩尔）诱导的血管加压素反应。静脉内预先注射纳洛酮（0.5毫克/千克体重）可减弱亮啡肽（60皮摩尔）对血管加压素分泌的抑制作用。此外，纳洛酮（0.5毫克/千克体重）可延长脑室内注射血管紧张素II（100皮摩尔）诱导的血管加压素分泌。这些结果表明，亮啡肽对血管加压素分泌具有强大的抑制作用，并且单独或与其他内源性阿片肽联合使用时，它在血管加压素分泌的控制中起重要作用。
