Neuromuscular and Neuroimmunology Service, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
J Neurol. 2020 Sep;267(9):2683-2691. doi: 10.1007/s00415-020-09916-y. Epub 2020 May 19.
A few observational studies and randomized trials suggest that exercise and rehabilitation may improve activity limitation and quality of life (QoL) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but the impact of other modifiable factors on the severity of the disease is not well understood. Using a structured questionnaire, we collected data on lifestyle and dietary habits of the patients included in the Italian CIDP database to investigate the possible influence of modifiable lifestyle factors on disability and QoL. Questionnaire data were available for 323 patients. The effect of lifestyle and dietary exposures on impairment, disability and QoL was evaluated using logistic regression models, adjusting for age, sex, disease duration, physical activity and smoking. Physical activity was associated with lower sensory impairment by the ISS scale, less disability by the INCAT and RODS scale and a better QoL in all the domains of EURO-QoL scale with the exception of anxiety/depression. None of the other parameters had an impact on these scales. This study adds evidence to the possible role of physical activity in improving symptom severity, disability and QoL in patients with CIDP. None of the other environmental factors investigated appeared to have an impact on the severity and health perception of CIDP.
一些观察性研究和随机试验表明，运动和康复可能会改善慢性炎症性脱髓鞘性多发性神经病（CIDP）患者的活动受限和生活质量（QoL），但其他可改变因素对疾病严重程度的影响尚不清楚。我们使用结构化问卷收集了意大利 CIDP 数据库中纳入患者的生活方式和饮食习惯数据，以研究可改变的生活方式因素对残疾和 QoL 的可能影响。问卷数据可用于 323 名患者。使用逻辑回归模型评估生活方式和饮食暴露对损伤、残疾和 QoL 的影响，调整了年龄、性别、疾病持续时间、体力活动和吸烟。体力活动与 ISS 量表的感觉损伤降低、INCAT 和 RODS 量表的残疾减少以及除焦虑/抑郁外，所有 EURO-QoL 量表领域的 QoL 更好相关。其他参数均未对这些量表产生影响。这项研究为体力活动在改善 CIDP 患者症状严重程度、残疾和 QoL 方面可能发挥的作用提供了更多证据。研究中未发现其他环境因素对 CIDP 的严重程度和健康感知有影响。
