Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Arch Osteoporos. 2020 May 19;15(1):75. doi: 10.1007/s11657-020-00759-8.
This study aims to evaluate factors affecting the quality of life (QOL) of hypoparathyroidism. While QOL is reduced in post-surgical and non-surgical groups, mental health seems to be less affected in non-surgical patients. Having an additional disease affects QOL negatively but having thyroid cancer may not change the QOL results.
Hypoparathyroidism (HypoPT) is an orphan disease, which causes physical, emotional, and cognitive problems. We aimed to estimate the factors affecting the quality of life (QOL) of HypoPT patients.
Basal characteristics, treatments, and laboratory results of the participants were recorded. QOL of the patients and controls were evaluated via the Short Form-36 (SF-36) survey.
One hundred sixty HypoPT patients were compared with 148 controls. Patients had lower scores in all SF-36 domains than controls. Non-surgical patients had better scores in vitality and mental health compared with post-surgical ones. Males had higher scores in mental and physical health domains than females. Non-surgical patients had higher scores in mental health compared with post-surgical ones when calcium levels were between 8 and 8.9 mg/dL. When we compared the patients with the pathological results, QOL scores of post-surgical patients with thyroid cancer were not different from the patients with thyroid nodular hyperplasia. HypoPT patients having an additional disease presented lower scores in physical functions and general health. Disease duration was found out positively correlated with vitality in non-surgical patients.
While QOL is reduced in both post-surgical and non-surgical HypoPT groups, mental health seems to be less affected in non-surgical patients. Non-surgical patients might be tolerating hypocalcemia symptoms, lower calcium levels, and longer disease duration better than post-surgical ones. Having an additional disease affects the QOL negatively but having thyroid cancer may not change the QOL results of post-surgical patients.
甲状旁腺功能减退症（HypoPT）是一种孤儿病，可导致身体、情绪和认知问题。我们旨在评估影响 HypoPT 患者生活质量（QOL）的因素。
记录参与者的基本特征、治疗方法和实验室结果。通过 36 项简短健康调查问卷（SF-36）评估患者和对照组的 QOL。
将 160 例 HypoPT 患者与 148 例对照组进行比较。患者在所有 SF-36 领域的得分均低于对照组。与手术后患者相比，非手术患者在活力和心理健康方面的得分更高。男性在心理健康和身体健康方面的得分高于女性。当血钙水平在 8 至 8.9mg/dL 之间时，非手术患者的心理健康评分高于手术后患者。当我们将患者与病理结果进行比较时，患有甲状腺癌的手术后患者的 QOL 评分与患有甲状腺结节性增生的患者没有差异。患有其他疾病的 HypoPT 患者在身体功能和总体健康方面的得分较低。非手术患者的疾病持续时间与活力呈正相关。
尽管手术后和非手术后 HypoPT 组的 QOL 均降低，但非手术患者的心理健康似乎受影响较小。非手术患者可能比手术后患者更好地耐受低钙血症症状、较低的血钙水平和较长的疾病持续时间。患有其他疾病会对 QOL 产生负面影响，但患有甲状腺癌可能不会改变手术后患者的 QOL 结果。
