Jørgensen Camilla Uhre, Homøe Preben, Dahl Morten, Hitz Mette Friberg
Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital (ZUH) Køge Denmark.
Department of Medical Endocrinology Zealand University Hospital (ZUH) Køge Denmark.
JBMR Plus. 2021 Mar 16;5(4):e10479. doi: 10.1002/jbm4.10479. eCollection 2021 Apr.
Chronic hypoparathyroidism (HypoPT) is a common complication after total thyroidectomy and it impacts affected patients' quality of life (QoL). This study aimed to assess the QoL in patients with chronic HypoPT independently from their concurrent hypothyroidism and other comorbidities. For this purpose a follow-up study was performed, including 14 patients who developed chronic HypoPT after total thyroidectomy and 28 age- and sex-matched patients who had intact parathyroid function after total thyroidectomy. We used the RAND Short Form 36 Health Survey (SF-36) to compare the QoL between patients with or without chronic HypoPT. Chronic HypoPT patients had lower QoL scores in all domains of the RAND-SF-36 questionnaire and significant impairment in six of eight domains after adjustment for relevant confounders. They were more often operated because of a toxic diagnosis ( = .01), often being Graves disease. Additionally adjusting for surgical indications resulted in three of eight domains being significant affected. Chronic HypoPT is associated with significantly impairment of QoL, independently of the concurrent disease of hypothyroidism, comorbidities, and prospective values of TSH and serum (se)-ionized-Ca. There is a need for more focus and better treatment of patients experiencing chronic HypoPT after surgery. © 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
慢性甲状旁腺功能减退症（HypoPT）是全甲状腺切除术后常见的并发症，会影响患者的生活质量（QoL）。本研究旨在独立于慢性HypoPT患者同时存在的甲状腺功能减退症和其他合并症，评估其生活质量。为此，我们进行了一项随访研究，纳入了14例全甲状腺切除术后发生慢性HypoPT的患者，以及28例全甲状腺切除术后甲状旁腺功能正常、年龄和性别匹配的患者。我们使用兰德36项健康调查简表（SF-36）比较有无慢性HypoPT患者的生活质量。慢性HypoPT患者在兰德-36项调查问卷的所有领域生活质量得分较低，在调整相关混杂因素后，八个领域中有六个领域存在显著损害。他们因毒性诊断（P = 0.01）而接受手术的情况更为常见，通常是格雷夫斯病。此外，对手术指征进行调整后，八个领域中有三个领域受到显著影响。慢性HypoPT与生活质量的显著损害相关，与同时存在的甲状腺功能减退症、合并症以及促甲状腺激素（TSH）和血清（se）离子钙的预期值无关。对于术后出现慢性HypoPT的患者，需要更多关注并进行更好的治疗。© 2021作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
