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本文引用的文献

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Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH) with anti-inflammatory activity in the mouse models of colitis.新型二肽基肽酶 IV 抑制剂（Tyr-Pro-D-Ala-NH）具有抗炎活性，可用于结肠炎模型的小鼠。
Peptides. 2018 Oct;108:34-45. doi: 10.1016/j.peptides.2018.08.011. Epub 2018 Sep 1.
2
Digested Early Preterm Human Milk Suppresses Tumor Necrosis Factor-induced Inflammation and Cytotoxicity in Intestinal Epithelial Cells.消化早期早产儿人乳可抑制肿瘤坏死因子诱导的肠上皮细胞炎症和细胞毒性。
J Pediatr Gastroenterol Nutr. 2018 Jun;66(6):e153-e157. doi: 10.1097/MPG.0000000000001932.
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Identification of New Anti-inflammatory Peptides from Zein Hydrolysate after Simulated Gastrointestinal Digestion and Transport in Caco-2 Cells.模拟胃肠道消化及在Caco-2细胞中转运后从玉米醇溶蛋白水解物中鉴定新型抗炎肽
J Agric Food Chem. 2018 Feb 7;66(5):1114-1120. doi: 10.1021/acs.jafc.7b04562. Epub 2018 Jan 24.
4
Anti-inflammatory effects of egg yolk livetins (α, β, and γ-livetin) fraction and its enzymatic hydrolysates in lipopolysaccharide-induced RAW 264.7 macrophages.蛋黄卵转铁蛋白（α、β 和 γ-卵转铁蛋白）馏分及其酶解产物对脂多糖诱导的 RAW 264.7 巨噬细胞的抗炎作用。
Food Res Int. 2017 Oct;100(Pt 1):449-459. doi: 10.1016/j.foodres.2017.07.032. Epub 2017 Jul 18.
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The potential of food protein-derived anti-inflammatory peptides against various chronic inflammatory diseases.食物蛋白衍生的抗炎肽对各种慢性炎症性疾病的治疗潜力。
J Sci Food Agric. 2016 May;96(7):2303-11. doi: 10.1002/jsfa.7600. Epub 2016 Feb 18.
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Diversity of Intestinal Macrophages in Inflammatory Bowel Diseases.炎症性肠病中肠道巨噬细胞的多样性
Front Immunol. 2015 Dec 7;6:613. doi: 10.3389/fimmu.2015.00613. eCollection 2015.
7
Anti-inflammatory Effects of Poly-L-lysine in Intestinal Mucosal System Mediated by Calcium-Sensing Receptor Activation.钙敏感受体激活介导多聚赖氨酸对肠道黏膜系统的抗炎作用。
J Agric Food Chem. 2015 Dec 9;63(48):10437-47. doi: 10.1021/acs.jafc.5b03812. Epub 2015 Nov 20.
8
Noni (Morinda citrifolia L.) Fruit Extracts Improve Colon Microflora and Exert Anti-Inflammatory Activities in Caco-2 Cells.诺丽（海巴戟天）果实提取物改善结肠微生物群并在Caco-2细胞中发挥抗炎活性。
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9
Hydrolysate from eggshell membrane ameliorates intestinal inflammation in mice.蛋壳膜水解产物可改善小鼠肠道炎症。
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A review on chemical-induced inflammatory bowel disease models in rodents.化学诱导的啮齿动物炎症性肠病模型研究综述。
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玉米蛋白水解物的模拟胃肠道消化物可减轻Caco-2细胞和结肠炎小鼠模型中的炎症。

Simulated gastrointestinal digests of corn protein hydrolysate alleviate inflammation in caco-2 cells and a mouse model of colitis.

作者信息

Liang Qiufang, Ren Xiaofeng, Chalamaiah Meram, Ma Haile

机构信息

1School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013 Jiangsu China.

2Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Centre, University of Alberta, Edmonton, AB Canada.

出版信息

J Food Sci Technol. 2020 Jun;57(6):2079-2088. doi: 10.1007/s13197-020-04242-7. Epub 2020 Jan 29.

DOI:10.1007/s13197-020-04242-7
PMID:32431334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7230093/
Abstract

Inflammatory bowel disease, a typical chronic inflammatory disease of the gastrointestinal tract, make up a growing share of the global disease burden. This study firstly evaluated the anti-inflammatory effects of corn protein hydrolysate (CPH) using a cell model of tumor cell necrosis factor-α (TNF-α)-induced inflammation and a mouse model of colitis induced by dextran sodium sulfate. CPH digests significantly inhibited the expression of cyclooxygenase-2 and inducible nitric oxide synthase, and reduced the secretion of interleukin-8 in TNF-α-induced inflammation in Caco-2 cells. In mice, CPH digests significantly improved the body weight loss, clinical scores, shortening of the colon and histological symptoms, and decreased the myeloperoxidase activity, and down regulated the expression of TNF-α, and interleukin-6 in the colon. The above results indicate that the CPH can potentially be used as a health food/nutraceutical for the treatment/management of intestinal inflammation.

摘要

炎症性肠病是一种典型的胃肠道慢性炎症性疾病，在全球疾病负担中所占比例日益增加。本研究首先使用肿瘤细胞坏死因子-α（TNF-α）诱导炎症的细胞模型和葡聚糖硫酸钠诱导的结肠炎小鼠模型，评估了玉米蛋白水解物（CPH）的抗炎作用。CPH消化物显著抑制环氧合酶-2和诱导型一氧化氮合酶的表达，并减少Caco-2细胞中TNF-α诱导炎症时白细胞介素-8的分泌。在小鼠中，CPH消化物显著改善体重减轻、临床评分、结肠缩短和组织学症状，降低髓过氧化物酶活性，并下调结肠中TNF-α和白细胞介素-6的表达。上述结果表明，CPH有可能用作治疗/管理肠道炎症的保健食品/营养保健品。