Shi Yaning, Rupa Prithy, Jiang Bo, Mine Yoshinori
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Department of Food Science, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.
Int J Mol Sci. 2014 Dec 9;15(12):22728-42. doi: 10.3390/ijms151222728.
Inflammatory bowel diseases (IBD) comprises of ulcerative colitis (UC) and Cohn's disease (CD) as two main idiopathic pathologies resulting in immunologically mediated chronic inflammatory conditions. Several bioactive peptides and hydro lysates from natural sources have now been tested in animal models of human diseases for potential anti-inflammatory effects. Eggshell membrane (ESM) is a well-known natural bioactive material. In this study, we aim to study the anti-inflammatory activity of ESM hydro lysate (AL-PS) in vitro and in vivo. In vitro, AL-PS was shown to inhibit pro-inflammatory cytokine IL-8 secretion. In vivo treatment with AL-PS was shown to reduce dextran sodium sulphate (DSS)-induced weight loss, clinical signs of colitis and secretion of interleukin (IL)-6 (p < 0.05). In addition, treatment with AL-PS also attenuated the severity of intestinal inflammation via down-regulation of IL-10 an anti-inflammatory cytokine. This validates potential benefits of AL-PS as a novel preventative target molecule for treatment of IBD.
炎症性肠病（IBD）由溃疡性结肠炎（UC）和克罗恩病（CD）组成，是导致免疫介导的慢性炎症状态的两种主要特发性疾病。目前，几种来自天然来源的生物活性肽和水解产物已在人类疾病的动物模型中进行了测试，以探究其潜在的抗炎作用。蛋壳膜（ESM）是一种著名的天然生物活性材料。在本研究中，我们旨在研究蛋壳膜水解产物（AL-PS）在体外和体内的抗炎活性。在体外，AL-PS被证明可抑制促炎细胞因子IL-8的分泌。在体内，用AL-PS治疗可减轻葡聚糖硫酸钠（DSS）诱导的体重减轻、结肠炎的临床症状以及白细胞介素（IL）-6的分泌（p<0.05）。此外，用AL-PS治疗还通过下调抗炎细胞因子IL-10减轻了肠道炎症的严重程度。这证实了AL-PS作为治疗IBD的新型预防性靶分子的潜在益处。
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