Joshi Abhishek, Soni Arun, Acharya Sanjeev
Department of Pharmacology, SSR College of Pharmacy, Union Territory of Dadra 396230 Sayli, Silvassa, India.
Department of Pharmacognosy, SSR College of Pharmacy, Union Territory of Dadra 396230 Sayli, Silvassa, India.
In Vitro Model. 2022;1(3):213-227. doi: 10.1007/s44164-022-00017-w. Epub 2022 Apr 25.
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition. Ulcerative colitis and Crohn's disease are types of inflammatory bowel disease. Over many decades, the disease has been a topic of study, with experts still trying to figure out its cause and pathology. Researchers have established many in vivo animal models, in vitro cell lines, and ex vivo systems to understand its cause ultimately and adequately identify a therapy. However, in vivo animal models cannot be regarded as good models for studying IBD since they cannot completely simulate the disease. Furthermore, because species differences are a crucial subject of concern, in vitro cell lines and ex vivo systems can be employed to recreate the condition properly. In vitro models serve as the starting point for biological and medical research. Ex vivo and in vitro models for replicating gut physiology have been developed. This review aims to present a clear understanding of several in vitro and ex vivo models of IBD and provide insights into their benefits and limits and their value in understanding intestinal physiology.
炎症性肠病（IBD）是一种慢性复发性胃肠道疾病。溃疡性结肠炎和克罗恩病是炎症性肠病的类型。几十年来，该疾病一直是研究的课题，专家们仍在试图弄清楚其病因和病理。研究人员建立了许多体内动物模型、体外细胞系和离体系统，以最终了解其病因并充分确定治疗方法。然而，体内动物模型不能被视为研究IBD的良好模型，因为它们不能完全模拟该疾病。此外，由于物种差异是一个关键的关注问题，可以采用体外细胞系和离体系统来恰当地重现病情。体外模型是生物学和医学研究的起点。已经开发出用于复制肠道生理的离体和体外模型。本综述旨在清晰地阐述几种IBD的体外和离体模型，并深入探讨它们的优点和局限性以及它们在理解肠道生理方面的价值。
