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通过测量黄体早期(峰值日+3)孕酮生成量来识别排卵后不孕症。

The Identification of Postovulation Infertility with the Measurement of Early Luteal Phase (Peak Day +3) Progesterone Production.

作者信息

Hilgers Thomas W

机构信息

Saint Paul VI Institute for the Study of Human Reproduction, Omaha, NE, USA.

Department of Obstetrics and Gynecology, School of Medicine, Creighton University, Omaha, NE, USA.

出版信息

Linacre Q. 2020 Feb;87(1):78-84. doi: 10.1177/0024363919885551. Epub 2019 Nov 13.

Abstract

UNLABELLED

This study reports on 632 cycles from 105 women who were using the CREIGHTON MODEL Fertility™ System to avoid pregnancy and had either a serious reason to avoid pregnancy or some degree of a lack of confidence. A progesterone level was drawn on the third day after the Peak Day as they were charting, and if the progesterone level was 2.3 ng/mL or greater, then ovulation was determined to have passed. If the level was greater than 3.0 ng/mL, this indicated that an absolute period of infertility had begun. In these cases, no pregnancies were observed. In the 27 cycles in which a specific follow-up relative to pregnancy could not be definitively determined, the progesterone levels in all cases were 2.3 ng/mL or greater with 23 of the 27 cycles being 3.1 ng/mL or greater. It is highly unlikely that any of those became pregnant as well. These cycles were collected over thirteen years (2004-2016). Two case presentations are also a part of this article of two families in which the couples had very serious reasons to avoid pregnancy. In these two couples, each of the women was multi-gravid and had no evidence of subfertility or infertility. They used the family planning progesterone level (the Peak Day +3 progesterone level) for a total of 167 cycles over a number of years successfully without a subsequent pregnancy.

SUMMARY

This article presents a thirteen-year effort to evaluate the serum progesterone level on the third day after the Peak Day as observed by women charting the CREIGHTON MODEL Fertility™ System. It is known that the Peak Day is associated with ovulation, and if the progesterone reaches a certain level, then an absolute period of infertility should follow. In fact, this is what this study reflects.

摘要

未标注

本研究报告了105名使用克里顿生育模式系统来避免怀孕的女性的632个周期,这些女性要么有避免怀孕的严重理由,要么某种程度上缺乏信心。在她们绘制图表时,在峰值日之后的第三天检测孕酮水平,如果孕酮水平为2.3纳克/毫升或更高,则确定排卵已经过去。如果水平大于3.0纳克/毫升,这表明绝对不孕期已经开始。在这些情况下,未观察到怀孕。在27个无法明确确定与怀孕相关的具体随访情况的周期中,所有病例的孕酮水平均为2.3纳克/毫升或更高,其中27个周期中有23个为3.1纳克/毫升或更高。这些周期中任何一个怀孕的可能性都极小。这些周期是在13年(2004 - 2016年)内收集的。本文还包括两个病例报告,涉及两个家庭,这两对夫妇都有非常严重的理由避免怀孕。在这两对夫妇中,每位女性都有多次妊娠史,且没有亚生育力或不孕的证据。她们在多年内总共使用计划生育孕酮水平(峰值日 +3孕酮水平)167个周期,均成功避免了后续怀孕。

总结

本文展示了一项为期13年的努力,旨在评估使用克里顿生育模式系统绘制图表的女性在峰值日之后第三天的血清孕酮水平。已知峰值日与排卵相关,如果孕酮达到一定水平,那么随后应进入绝对不孕期。事实上,本研究反映的正是如此。

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