Shepard M K, Senturia Y D
Fertil Steril. 1977 May;28(5):541-8. doi: 10.1016/s0015-0282(16)42554-9.
An endometrial biopsy and a blood sample for progesterone determination obtained simultaneously in the midluteal phase of the cycles of 55 infertile women were compared for reliability for confirmation of presumptive ovulation and evaluation of luteal function. Progesterone levels of 3 ng/ml or greater were found in 90.5% of the cycles. Secretory endometrium was identified in 81% of the cycles. Thirty-three cycles yielded sufficient information to compare the two methods for evaluation of luteal function. Histology and progesterone levels were consistent with each other and the presumed time of ovulation in only 11 cycles. Histology was inconsistent with the presumed time of ovulation in 20 cycles, while progesterone was inconsistent in only two cycles. Additional samples for progesterone determinations were obtained during the biopsy cycles of 15 patients who presented adequate data for evaluation of luteal function. A single, well-timed progesterone determination appeared adequately to reflect the data obtained from serial samples in the same cycle. These results support the thesis that a single, well-timed serum progesterone determination is superior to a single endometrial biopsy as a screening method for confirmation of presumptive ovulation and for evaluation of luteal function.
对55名不孕妇女在月经周期黄体中期同时进行子宫内膜活检和采集血样测定孕酮，比较二者在确认推测排卵和评估黄体功能方面的可靠性。在90.5%的周期中发现孕酮水平≥3 ng/ml。在81%的周期中发现有分泌期子宫内膜。33个周期产生了足够的信息来比较两种评估黄体功能的方法。组织学和孕酮水平仅在11个周期中与推测的排卵时间一致。组织学与推测的排卵时间在20个周期中不一致，而孕酮仅在2个周期中不一致。在15名有足够数据评估黄体功能的患者的活检周期中，额外采集了孕酮测定样本。一次时机恰当的孕酮测定似乎足以反映同一周期中连续样本获得的数据。这些结果支持这样的论点，即作为确认推测排卵和评估黄体功能的筛查方法，一次时机恰当的血清孕酮测定优于单次子宫内膜活检。
