Didzhiapetrene Ia K, Shukialene D F, Dzhiuvene D A, Degutis Iu A
Eksp Onkol. 1988;10(6):57-9.
Certain derivatives of phenolselenonic acid, namely ammonium, calcium, potassium, and sodium 3-acetoxy-4-methoxybenzolselenonates as well as the corresponding derivatives of 3-hydroxy-4-methoxybenzolselenonic acid were studied. These compounds were tested for anticarcinogenic activity against urethane-induced pulmonary adenomas and for antitumoral activity against some transplanted tumours such as leukemia L 1210, mammary adenocarcinoma Ca 755 and Walker carcinosarcoma 256. These compounds were found to produce more intensive anticarcinogenic action than antitumoral one. The results showed that ammonium 3-acetoxy-4-methoxybenzolselenonate given before the injection of urethane or together with urethane exert a significant influence on adenomas, while calcium 3-hydroxy-4-methoxybenzolselenonate inhibited the formation of adenomas at various stages of their development.
对苯亚硒酸的某些衍生物，即3-乙酰氧基-4-甲氧基苯亚硒酸铵、钙、钾和钠盐以及3-羟基-4-甲氧基苯亚硒酸的相应衍生物进行了研究。测试了这些化合物对尿烷诱导的肺腺瘤的抗癌活性以及对一些移植肿瘤如白血病L 1210、乳腺腺癌Ca 755和沃克癌肉瘤256的抗肿瘤活性。发现这些化合物产生的抗癌作用比抗肿瘤作用更强。结果表明，在注射尿烷之前或与尿烷一起给予3-乙酰氧基-4-甲氧基苯亚硒酸铵对腺瘤有显著影响，而3-羟基-4-甲氧基苯亚硒酸钙在腺瘤发展的各个阶段均抑制其形成。
