Dricken Julie, Pettke Erica, Griffin John A, Li Henry Y, Mehta Vivek
Colon and Rectal Clinic, Swedish Cancer Institute, Seattle, USA.
Department of Oncology and Hematology, Polyclinic, Seattle, USA.
Cureus. 2020 Apr 18;12(4):e7724. doi: 10.7759/cureus.7724.
Capecitabine, a prodrug of fluorouracil, is a component of many chemotherapy regimens used to treat a wide variety of malignancies. One of the most common adverse reactions experienced by those who have been exposed to capecitabine is palmar-plantar erythrodysesthesia (PPE). PPE is a cutaneous manifestation of chemotherapy-related drug toxicity that has signs and symptoms of erythema, edema, pain, ulceration, or desquamation of the palms of the hands and soles of the feet. The signs and symptoms occur with varying severity. There are few reports of the genitalia being similarly affected. The following case describes a patient with locally advanced rectal cancer who experienced erythrodysesthesia secondary to a capecitabine-containing neoadjuvant chemoradiation regimen that primarily and most significantly involved the genitalia.
卡培他滨是氟尿嘧啶的前体药物，是用于治疗多种恶性肿瘤的许多化疗方案的组成部分。接触过卡培他滨的人最常见的不良反应之一是手足红斑感觉异常（PPE）。PPE是化疗相关药物毒性的一种皮肤表现，其体征和症状包括手掌和脚底的红斑、水肿、疼痛、溃疡或脱皮。这些体征和症状的严重程度各不相同。很少有关于生殖器受到类似影响的报道。以下病例描述了一名局部晚期直肠癌患者，该患者在接受含卡培他滨的新辅助放化疗方案后出现感觉异常，主要且最显著地累及生殖器。
