Risum Signe, Langer Seppo W
Onkologisk Klinik, Finsencentret 5073, H:S Rigshospitalet, DK-2100 København ø.
Ugeskr Laeger. 2003 Aug 11;165(33):3161-2.
Palmar-plantar erythrodysesthesia (PPE, hand-foot syndrome) is a relatively frequent cutaneous toxicity related to antineoplastic treatment with e.g. fluorouracil, capecitabine, and liposomal doxorubicin. It usually presents as paresthesia and painful erythema of the palms and soles and may lead to ulceration of the skin. The symptoms are dose-dependent, and the condition may be dose-limiting. Two cases of chemotherapy-associated PPE are presented.
手足红斑性感觉异常（PPE，手足综合征）是一种相对常见的与抗肿瘤治疗相关的皮肤毒性反应，例如与氟尿嘧啶、卡培他滨和脂质体阿霉素有关。它通常表现为手掌和足底的感觉异常及疼痛性红斑，可能导致皮肤溃疡。症状呈剂量依赖性，这种情况可能会限制剂量。本文介绍了两例与化疗相关的PPE病例。
