ArnD 是一种参与多黏菌素耐药的脱甲酰基酶。
ArnD is a deformylase involved in polymyxin resistance.
机构信息
Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
出版信息
Chem Commun (Camb). 2020 Jun 25;56(50):6830-6833. doi: 10.1039/d0cc02241a. Epub 2020 May 20.
PMID:32432293
Abstract
The modification of lipid A with cationic 4-amino-4-deoxy-l-arabinose residues serves to confer resistance against cationic peptide antibiotics in Gram-negative bacteria. In this work, the enzyme ArnD is shown to act as a metal-dependent deformylase in the biosynthesis of this carbohydrate.
摘要
脂质 A 的修饰与阳离子 4-氨基-4-去氧-L-阿拉伯糖残基结合，使革兰氏阴性菌能够抵抗阳离子肽抗生素。在这项工作中，酶 ArnD 被证明在这种碳水化合物的生物合成中作为一种金属依赖性脱甲酰酶发挥作用。
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