Nofal Ahmad, Fouda Ibrahim, Aboelwafa Hany, Fawzy Mohamed M
Dermatology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Interactive Dermatology Research Group, Cairo, Egypt.
J Cosmet Dermatol. 2021 Jan;20(1):295-299. doi: 10.1111/jocd.13496. Epub 2020 May 30.
Doughnut warts, also called ring or annular warts, are a distinctive type of warts with central clearing and annular recurrence. There are very few studies illustrating this uncommon phenomenon and its treatment.
To present 15 cases of doughnut warts and evaluate the efficacy and safety of Candida antigen intralesional immunotherapy in their treatment.
The study included 15 patients presenting with doughnut warts who were previously treated with destructive modalities for their original warts. All patients were injected intralesionally by Candida antigen at a dose of 0.2 mL into the base of doughnut wart until complete clearance or for a maximum of 5 sessions.
Complete clearance was achieved in 12 patients (80%), partial response in 2 patients (13.3%), and no response in 1 patient (6.7%). Complete response was observed after two sessions in 5 patients, after three sessions in 4 patients, and after four sessions in 3 patients. Adverse effects were minimal and insignificant.
Doughnut warts represent a unique and rare type of wart recurrence. Intralesional Candida antigen immunotherapy seems to be a promising and effective therapeutic modality for the treatment of such a rare entity.
甜甜圈样疣，也称为环状或环形疣，是一种独特类型的疣，具有中央消退和环形复发的特点。很少有研究阐述这种不常见的现象及其治疗方法。
报告15例甜甜圈样疣病例，并评估皮损内注射念珠菌抗原免疫疗法治疗该病的有效性和安全性。
该研究纳入了15例患有甜甜圈样疣的患者，他们之前曾接受过针对其原始疣体的破坏性治疗。所有患者均在甜甜圈样疣的基底部皮损内注射0.2 mL念珠菌抗原，直至疣体完全清除或最多注射5次。
12例患者（80%）实现了完全清除，2例患者（13.3%）部分缓解，1例患者（6.7%）无反应。5例患者在2次注射后观察到完全缓解，4例患者在3次注射后完全缓解，3例患者在4次注射后完全缓解。不良反应轻微且不显著。
甜甜圈样疣代表一种独特且罕见的疣复发类型。皮损内注射念珠菌抗原免疫疗法似乎是治疗这种罕见疾病的一种有前景且有效的治疗方式。
