Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Eur J Cancer Care (Engl). 2020 Jul;29(4):e13247. doi: 10.1111/ecc.13247. Epub 2020 May 20.
The incidence of colorectal cancer (CRC) has been increasing in many Asian countries. This study aims to analyse trends in CRC incidence and histological patterns in Sri Lanka.
All newly diagnosed patients with CRC in Sri Lanka during 2001-2010 included in the National Cancer Registry were analysed for trends in incidence using Joinpoint regression software.
A total of 7,694 CRC (male:female = 1.02:1, mean age = 58.7 years) were analysed. The incidence of CRC in Sri Lanka has increased from a WHO age-standardised rate of 2.9/100,000 in 2001 (95%-confidence interval [95%-CI]: 2.64-3.16) to 6.08/100,000 in 2010 (95%-CI: 5.71-6.44). This is an estimated annual percentage change (EAPC) of 8.9 (95%-CI: 7.5-10.4). The proportional increase in incidence was observed to be greater for females (2.8 to 5.6, EAPC: 9.4 (95%-CI: 7.7-11.2), p < .05) than males (3.02 to 6.62, EAPC: 8.5 (95%-CI: 6.9-10.2), p < .05).
Similar to other Asian countries, a significant increase in the incidence of CRC was observed in Sri Lanka. Rate of the increase may have been artificially inflated due to better case reporting and diagnostic scrutiny. Future studies focussing on trends in tumour stage and fatality will help shed light on changing patterns in the burden of CRC in Sri Lanka.
在许多亚洲国家，结直肠癌（CRC）的发病率一直在上升。本研究旨在分析斯里兰卡 CRC 发病率和组织学模式的趋势。
分析 2001-2010 年期间斯里兰卡国家癌症登记处收录的所有新诊断 CRC 患者，使用 Joinpoint 回归软件分析发病率趋势。
共分析了 7694 例 CRC（男：女=1.02:1，平均年龄 58.7 岁）。斯里兰卡 CRC 的发病率从 2001 年的世卫组织年龄标准化率 2.9/100000（95%置信区间[95%CI]：2.64-3.16）增加到 2010 年的 6.08/100000（95%CI：5.71-6.44）。这相当于每年 8.9%的估计百分比变化（EAPC）（95%CI：7.5-10.4）。与男性（3.02-6.62，EAPC：8.5（95%CI：6.9-10.2），p<0.05）相比，女性（2.8-5.6，EAPC：9.4（95%CI：7.7-11.2））的发病率增长比例更大，p<0.05）。
与其他亚洲国家一样，斯里兰卡 CRC 的发病率也显著上升。由于更好的病例报告和诊断检查，发病率的增加可能被人为夸大。未来的研究集中在肿瘤分期和死亡率的趋势上，将有助于了解斯里兰卡 CRC 负担变化的模式。
