Department of Surgery, Faculty of Medicine, University of Colombo, Kynsey Road, , P.O. Box 271, Colombo 8, Western Province, Sri Lanka.
J Egypt Natl Canc Inst. 2023 Feb 21;35(1):3. doi: 10.1186/s43046-023-00163-6.
Laryngeal cancer is the ninth commonest cancer among Asian males. Global and regional epidemiological analyses have shown varying patterns in the incidence and risk factors for laryngeal cancer. Therefore, we aimed to analyse the trends in the incidence and histological patterns of laryngeal cancers for the first time in Sri Lanka.
We used the population-based Sri Lanka cancer registry data and pooled all newly diagnosed patients with laryngeal malignancies from 2001 to 2019 (a 19-year study period). The WHO age-standardised incidence rates (ASR) were calculated using the WHO standard pollution. We used the Joinpoint regression software to calculate the estimated annual percentage change (EAPC) and analysed the trends in the incidence by different age categories and sex.
From 2001 to 2019, 9808 new cases of laryngeal cancers (males = 8927, 91%, mean age = 62 years) were registered. The incidence of laryngeal cancers was greatest in the 70-74-year followed by 65-69-year age groups. Around 7.9% were reported as carcinoma not otherwise specified (NOS). Squamous cell carcinoma (90.1%) was the commonest documented histology type. A rise in the WHO-ASR was noted from 1.91 per 100,000 in 2001 [95% confidence interval (95% CI): 1.69-2.12] to 3.59 per 100,000 in 2017 [(95% CI: 3.34-3.84); EAPC: 4.4 (95% CI: 3.7-5.2), p < 0.05 for trend] followed by a decrease in the incidence [2.97 per 100,000 in 2019 (95% CI: 2.74-3.2), EAPC: - 7.2 (95% CI: - 21.1-9.1, p > 0.05)]. From 2001 to 2017, the proportional increase in incidence was greater in males than females [EAPC: 4.9 (95% CI: 4.1-5.7 vs. 3.7 (95% CI: 1.7-5.6)].
We identified an increasing incidence of laryngeal cancer in Sri Lanka from 2001 to 2017 followed by a slight decrease. Further studies are essential to identify the aetiological factors. Development of laryngeal cancer prevention and screening programmes for high-risk populations may be considered.
喉癌是亚洲男性中第九种最常见的癌症。全球和区域流行病学分析表明，喉癌的发病率和危险因素存在不同模式。因此，我们旨在首次分析斯里兰卡喉癌的发病率和组织学模式趋势。
我们使用基于人群的斯里兰卡癌症登记处数据，汇总了 2001 年至 2019 年（19 年研究期间）所有新诊断的喉恶性肿瘤患者。使用世界卫生组织标准污染计算了世界卫生组织年龄标准化发病率（ASR）。我们使用 Joinpoint 回归软件计算了估计的年百分比变化（EAPC），并按不同年龄组和性别分析了发病率趋势。
2001 年至 2019 年，登记了 9808 例新的喉癌病例（男性=8927 例，91%，平均年龄=62 岁）。70-74 岁年龄组和 65-69 岁年龄组的喉癌发病率最高。约有 7.9%报告为未特指的癌（NOS）。鳞状细胞癌（90.1%）是最常见的有记录的组织学类型。2001 年，世界卫生组织-ASR 从每 10 万人 1.91 上升至 2017 年的每 10 万人 3.59（95%置信区间（95%CI）：3.34-3.84）；EAPC：4.4（95%CI：3.7-5.2），p<0.05 趋势），随后发病率下降[2019 年每 10 万人 2.97（95%CI：2.74-3.2），EAPC：-7.2（95%CI：-21.1-9.1，p>0.05）]。2001 年至 2017 年，男性的发病率呈上升趋势，而女性则呈上升趋势。EAPC：4.9（95%CI：4.1-5.7 vs. 3.7（95%CI：1.7-5.6）。
我们发现，2001 年至 2017 年，斯里兰卡喉癌的发病率呈上升趋势，随后略有下降。有必要进一步研究以确定病因。可以考虑为高危人群制定喉癌预防和筛查计划。
