Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Division of Hospital Medicine, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky.
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1280-L1281. doi: 10.1152/ajplung.00153.2020. Epub 2020 May 20.
There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.
在当前的 2019 年冠状病毒病（COVID-19）大流行中，存在明显的性别二态性。在这里，我们报告雌激素可以调节血管紧张素转换酶 2（ACE2）的表达，ACE2 是严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）进入细胞的关键成分，在分化的气道上皮细胞中。需要进一步研究来阐明性激素调节 SARS-CoV-2 感染性的机制。
