雌激素调节分化气道上皮细胞中 SARS-CoV-2 受体 ACE2 的表达。
Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells.
机构信息
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Division of Hospital Medicine, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky.
出版信息
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1280-L1281. doi: 10.1152/ajplung.00153.2020. Epub 2020 May 20.
Abstract
There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.
摘要
在当前的 2019 年冠状病毒病（COVID-19）大流行中，存在明显的性别二态性。在这里，我们报告雌激素可以调节血管紧张素转换酶 2（ACE2）的表达，ACE2 是严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）进入细胞的关键成分，在分化的气道上皮细胞中。需要进一步研究来阐明性激素调节 SARS-CoV-2 感染性的机制。
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