Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Ann Palliat Med. 2020 May;9(3):957-966. doi: 10.21037/apm-20-691. Epub 2020 May 10.
Type 2 diabetes mellitus (T2DM) is associated with a large number of genetic variants of melatonin receptor 1B (MTNR1B), but the results of studies involving different racial groups have been inconsistent. Thus, we carried out a meta-analysis to evaluate the correlation between the MTNR1B variants and T2DM in the Chinese population.
A systematic search was conducted of English-language databases including PubMed, Embase, and Medline, and Chinese-language databases including China National Knowledge Infrastructure (CNKI), Wanfang Database, and CQVIP to collect relevant articles published up to January 31, 2020. Count data were pooled using odds ratio (OR) and 95% confidence interval (CI), and the analysis was performed using the "meta" package of the R3.5.1 software.
Nine articles involving 10,127 subjects in the T2DM group and 10,885 subjects in the healthy control group were entered into the final analysis. Four articles reported the rs1387153 variant of the MTNR1B gene in Chinese populations. Meta-analysis showed there to be no correlation between the C-allele and TT genotype and the occurrence of T2DM. However, a subgroup analysis based on the HardyWeinberg equilibrium (HWE) revealed that the frequency of the CC genotype was significantly lower in the T2DM group than in the control group (OR: 0.88; 95% CI: 0.78, 1.00; P=0.049). Seven articles reported the rs10830963 variant of the MTNR1B gene among Chinese populations. Meta-analysis discovered that the G-allele was correlated with the T2DM occurrence. The frequency of the G-allele in the T2DM group was 1.07 times that in the control group (95% CI: 1.02, 1.12). The GG genotype was associated with the occurrence of T2DM, with its frequency in the T2DM group 1.15 times that in the control group (95% CI: 1.05, 1.25) (P<0.05); however, there was no correlation between the CC genotype and T2DM.
There is a correlation between the CC genotype of the rs1387153 variant in the MTNR1B gene and T2DM in the Chinese population, although this finding needs to be verified in studies with large sample sizes. The G-allele and GG genotype of the rs10830963 variant in the MTNR1B gene are associated with the occurrence of T2DM.
2 型糖尿病（T2DM）与褪黑素受体 1B（MTNR1B）的大量遗传变异有关，但涉及不同种族群体的研究结果并不一致。因此，我们进行了荟萃分析，以评估 MTNR1B 变异与中国人群 T2DM 的相关性。
系统检索了英文数据库，包括 PubMed、Embase 和 Medline，以及中文数据库，包括中国知网（CNKI）、万方数据库和维普数据库，收集截至 2020 年 1 月 31 日发表的相关文章。使用比值比（OR）和 95%置信区间（CI）汇总计数数据，并使用 R3.5.1 软件的“meta”包进行分析。
最终纳入 10127 例 T2DM 组和 10885 例健康对照组的 9 篇文章进行最终分析。有 4 篇文章报道了中国人群 MTNR1B 基因 rs1387153 变异。荟萃分析显示，C 等位基因和 TT 基因型与 T2DM 的发生无相关性。然而，基于 Hardy-Weinberg 平衡（HWE）的亚组分析表明，CC 基因型在 T2DM 组中的频率明显低于对照组（OR：0.88；95%CI：0.78，1.00；P=0.049）。有 7 篇文章报道了中国人群 MTNR1B 基因 rs10830963 变异。荟萃分析发现，G 等位基因与 T2DM 的发生有关。T2DM 组 G 等位基因的频率是对照组的 1.07 倍（95%CI：1.02，1.12）。GG 基因型与 T2DM 的发生有关，T2DM 组的频率是对照组的 1.15 倍（95%CI：1.05，1.25）（P<0.05）；然而，CC 基因型与 T2DM 无关。
MTNR1B 基因 rs1387153 变异的 CC 基因型与中国人群的 T2DM 相关，尽管这一发现需要在大样本量的研究中进一步验证。MTNR1B 基因 rs10830963 变异的 G 等位基因和 GG 基因型与 T2DM 的发生有关。
