Gao Kaiping, Wang Jinjin, Li Linlin, Zhai Yujia, Ren Yongcheng, You Haifei, Wang Bingyuan, Wu Xuli, Li Jianna, Liu Zichen, Li Xiong, Huang Yaxin, Luo Xin-Ping, Hu Dongsheng, Ohno Kinji, Wang Chongjian
Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Department of Traditional Chinese Medicine Prevention, Preventive Medicine Research Evaluation Center, Henan University of Traditional Chinese Medicine, Zhengzhou 450001, China.
Int J Environ Res Public Health. 2016 Feb 26;13(3):260. doi: 10.3390/ijerph13030260.
Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls (p < 0.05). The AC and CC genotypes and the combined AC + CC genotype of rs151290 in KCNQ1 were associated with increases risk of T2DM before (OR = 1.482, 95% CI = 1.062-2.069; p = 0.021; OR = 1.544, 95% CI = 1.097-2.172, p = 0.013; and OR = 1.509, 95% CI = 1.097-2.077, p = 0.011, respectively) and after (OR = 1.539, 95% CI = 1.015-2.332, p = 0.042; OR = 1.641, 95% CI = 1.070-2.516, p = 0.023; and OR = 1.582, 95% CI = 1.061-2.358, p = 0.024; respectively) adjustment for sex, age, anthropometric measurements, biochemical indexes, smoking and alcohol consumption. Consistent with results of genotype analysis, the C allele of rs151290 in KCNQ1 was also associated with increased risk of T2DM (OR = 1.166, 95% CI = 1.004-1.355, p = 0.045). No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province.
KCNQ1基因rs151290、KLF14基因rs972283、GCKR基因rs780094以及MTNR1B基因rs10830963处的基因变异已被证实与2型糖尿病（T2DM）相关，但在中国人群中的研究结果存在矛盾。本研究旨在调查这四个单核苷酸多态性（SNP）与中国河南省大量汉族人群T2DM的相关性。对736例T2DM患者（病例组）和768例糖耐量正常的健康对照者进行KCNQ1基因rs151290、KLF14基因rs972283、GCKR基因rs780094以及MTNR1B基因rs10830963的基因分型。采用多因素logistic回归分析这四个基因中的基因变异与T2DM的相关性。病例组和对照组之间KCNQ1基因rs151290的基因型和等位基因分布存在显著差异（p < 0.05）。KCNQ1基因rs151290的AC和CC基因型以及AC + CC合并基因型与T2DM发病风险增加相关，调整性别、年龄、人体测量指标、生化指标、吸烟和饮酒因素后，发病前（OR = 1.482，95%CI = 1.062 - 2.069；p = 0.021；OR = 1.544，95%CI = 1.097 - 2.172，p = 由文本可知，该研究是关于特定基因变异与2型糖尿病在河南汉族人群中的相关性研究，通过对大量病例和对照进行基因分型及多因素分析，发现KCNQ1基因rs151290的某些基因型和等位基因与T2DM发病风险增加相关，而其他三个基因的变异未检测到与T2DM的关联。 0.013；OR = 1.509，95%CI = 1.097 - 2.077，p = 0.011）和发病后（OR = 1.539，95%CI = 1.015 - 2.332，p = 0.042；OR = 1.641，95%CI = 1.070 - 2.516，p = 0.023；OR = 1.582，95%CI = 1.061 - 2.358，p = 0.024）均如此。与基因型分析结果一致，KCNQ1基因rs151290的C等位基因也与T2DM发病风险增加相关（OR = 1.166，95%CI = 1.004 - 1.355，p = 0.045）。未检测到KLF14基因rs972283、GCKR基因rs780094或MTNR1B基因rs10830963的基因变异与T2DM之间存在关联。KCNQ1基因rs151290的AC和CC基因型以及C等位基因可能是河南汉族人群T2DM的危险因素。
