视黄醇摄入量与成年人高尿酸血症的关联。
Association between retinol intake and hyperuricaemia in adults.
机构信息
Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, People's Republic of China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao, People's Republic of China.
出版信息
Public Health Nutr. 2021 Jun;24(8):2205-2214. doi: 10.1017/S1368980020000324. Epub 2020 May 21.
OBJECTIVE
Current evidences on the association between hyperuricaemia and retinol intake remain inconsistent. Furthermore, no known studies have investigated the relationship between hyperuricaemia and retinol intake from animal food and plant food separately. This study aimed to assess the relationship between different sources of retinol intake and risk of hyperuricaemia among US adults.
DESIGN
Univariate and multivariate weighted logistic regression models and restricted cubic spline models were used to assess the associations of total, animal-derived and plant-derived retinol intakes with the risk of hyperuricaemia. Dietary retinol was measured through two 24-h dietary recall interviews. Hyperuricaemia was defined as serum uric acid level ≥7·0 and ≥6·0 mg/dl in men and women, respectively.
SETTING
Data from the National Health and Nutrition Examination Survey 2009-2014 were used in this cross-sectional study.
PARTICIPANTS
Overall, 12 869 participants aged ≥20 years were included.
RESULTS
Compared with the lowest quintile, the multivariable OR of hyperuricaemia for the highest quintile intake of total, animal-derived and plant-derived retinol were 0·71 (95 % CI 0·52, 0·96), 0·76 (95 % CI 0·59, 0·96) and 0·92 (95 % CI 0·72, 1·17), respectively. The inverse association between dietary intake of total retinol and the risk of hyperuricaemia was observed in men. Dose-response analyses revealed a novel linear trend between the risk of hyperuricaemia and total, animal-derived retinol intake separately.
CONCLUSIONS
Our findings indicated that intakes of total and animal-derived retinol were negatively associated with hyperuricaemia in US adults.
目的
目前关于高尿酸血症与视黄醇摄入量之间关联的证据仍不一致。此外，尚无已知的研究分别调查动物源性和植物源性食物中视黄醇摄入与高尿酸血症之间的关系。本研究旨在评估美国成年人不同来源的视黄醇摄入与高尿酸血症风险之间的关系。
设计
使用单变量和多变量加权逻辑回归模型和限制性三次样条模型来评估总视黄醇、动物源性视黄醇和植物源性视黄醇摄入量与高尿酸血症风险之间的关系。膳食视黄醇通过两次 24 小时膳食回顾访谈进行测量。高尿酸血症定义为血清尿酸水平男性≥7.0mg/dl，女性≥6.0mg/dl。
设置
本横断面研究使用了 2009-2014 年全国健康和营养调查的数据。
参与者
共纳入 12869 名年龄≥20 岁的参与者。
结果
与最低五分位相比，总视黄醇、动物源性视黄醇和植物源性视黄醇摄入量最高五分位的高尿酸血症多变量 OR 分别为 0.71（95%CI 0.52，0.96）、0.76（95%CI 0.59，0.96）和 0.92（95%CI 0.72，1.17）。男性膳食总视黄醇摄入量与高尿酸血症风险之间呈负相关。剂量-反应分析显示，总视黄醇和动物源性视黄醇摄入量与高尿酸血症风险之间存在新的线性趋势。
结论
我们的研究结果表明，美国成年人总视黄醇和动物源性视黄醇的摄入量与高尿酸血症呈负相关。
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