Xu Linhao, Jiang Hua
Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.
Front Plant Sci. 2020 May 6;11:452. doi: 10.3389/fpls.2020.00452. eCollection 2020.
In eukaryotes, histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. In , while it is well known that dimethylation of histone H3 at lysine 9 (H3K9me2) is maintained through a feedback loop between H3K9me2 and DNA methylation, the details of the H3K9me2-dependent silencing pathway have not been fully elucidated. Recently, the regulation and the function of H3K9 methylation have been extensively characterized. In this review, we summarize work from the recent studies regarding the regulation of H3K9me2, emphasizing the process of deposition and reading and the biological significance of H3K9me2 in .
在真核生物中，组蛋白H3赖氨酸9甲基化（H3K9me）通过阻止异常基因产物的表达和转座激活来介导侵袭性和重复序列的沉默。在……中，虽然众所周知组蛋白H3赖氨酸9二甲基化（H3K9me2）通过H3K9me2与DNA甲基化之间的反馈环得以维持，但H3K9me2依赖性沉默途径的细节尚未完全阐明。最近，H3K9甲基化的调控和功能已得到广泛表征。在本综述中，我们总结了近期有关H3K9me2调控的研究工作，重点强调了其沉积和识别过程以及H3K9me2在……中的生物学意义。
