Alshomar Khalid M, Altariqi Sulaiman M, Alrikabi Ammar C, Alkatan Hind M, Al-Faky Yasser H
Ophthalmology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ann Med Surg (Lond). 2020 May 7;55:1-4. doi: 10.1016/j.amsu.2020.04.028. eCollection 2020 Jul.
Extramedullary plasmacytomas (EMPs) are uncommon plasma cell tumors that develop in soft tissue as isolated tumors without osseous involvement while secondary lesions are associated with systemic multiple myeloma (MM). Primary extramedullary lesions are most commonly found in upper respiratory tract, gastrointestinal tract and lymph nodes. They can be found either in patients with history of MM or preceding the manifestation of a systemic disease. Orbital manifestation of the lesion is rare but conjunctival involvement is very unusual. The reported cases in the English-written literature are only five cases. Herein, we report the sixth case of primary EMP in a middle-aged adult who presented with a lesion confined to the conjunctiva, unremarkable present and past medical history, and confirmed tissue diagnosis. In addition, a review and summary of the previously reported cases in the literature is presented. We aim to attract the attention of ophthalmic surgeons to consider plasmacytoma within the differential diagnosis of a conjunctival lesion.
髓外浆细胞瘤（EMPs）是一种罕见的浆细胞肿瘤，发生于软组织，为孤立性肿瘤，无骨质受累，而继发性病变与系统性多发性骨髓瘤（MM）相关。原发性髓外病变最常见于上呼吸道、胃肠道和淋巴结。它们可在有MM病史的患者中发现，或在系统性疾病表现之前出现。该病变的眼眶表现罕见，但结膜受累非常不寻常。英文文献报道的病例仅有5例。在此，我们报告第六例原发性EMP，患者为中年成年人，病变局限于结膜，目前和既往病史无异常，组织诊断明确。此外，还对文献中先前报道的病例进行了回顾和总结。我们旨在引起眼科外科医生的注意，使其在结膜病变的鉴别诊断中考虑浆细胞瘤。
