用淀粉样蛋白负荷量测量唐氏综合征中的淀粉样蛋白积累。
Amyloid accumulation in Down syndrome measured with amyloid load.
作者信息
Zammit Matthew D, Laymon Charles M, Betthauser Tobey J, Cody Karly A, Tudorascu Dana L, Minhas Davneet S, Sabbagh Marwan N, Johnson Sterling C, Zaman Shahid H, Mathis Chester A, Klunk William E, Handen Benjamin L, Cohen Ann D, Christian Bradley T
机构信息
University of Wisconsin-Madison Waisman Center Madison Wisconsin.
Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania.
出版信息
Alzheimers Dement (Amst). 2020 Apr 16;12(1):e12020. doi: 10.1002/dad2.12020. eCollection 2020.
INTRODUCTION
Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load ( ) was recently developed as an alternative to standardized uptake value ratios (SUVrs) to quantify Aβ burden with high sensitivity for detecting and tracking Aβ change..
METHODS
was calculated in a DS cohort (N = 169, mean age ± SD = 39.6 ± 8.7 years) using [C-11]Pittsburgh compound B (PiB) PET imaging. DS-specific PiB templates were created for Aβ carrying capacity () and non-specific binding ().
RESULTS
The highest values of Aβ carrying capacity were found in the striatum and precuneus. Longitudinal changes in displayed less variability when compared to SUVrs.
DISCUSSION
These results highlight the utility of for characterizing Aβ deposition in DS. Rates of Aβ accumulation in DS were found to be similar to that observed in late-onset Alzheimer's disease (AD; ≈3% to 4% per year), suggesting that AD progression in DS is of earlier onset but not accelerated.
引言
唐氏综合征（DS）患者大脑中淀粉样β蛋白（Aβ）沉积增加。最近开发了一种新的淀粉样蛋白负荷正电子发射断层扫描（PET）指标（ ），作为标准化摄取值比率（SUVrs）的替代方法，用于量化Aβ负担，对检测和追踪Aβ变化具有高灵敏度。
方法
使用[C-11]匹兹堡化合物B（PiB）PET成像在一个DS队列（N = 169，平均年龄±标准差 = 39.6 ± 8.7岁）中计算 。为Aβ携带能力（ ）和非特异性结合（ ）创建了DS特异性PiB模板。
结果
在纹状体和楔前叶中发现Aβ携带能力的最高值。与SUVrs相比， 的纵向变化显示出较小的变异性。
讨论
这些结果突出了 在表征DS中Aβ沉积方面 的实用性。发现DS中Aβ积累率与晚发性阿尔茨海默病（AD；每年约3%至4%）中观察到的相似，这表明DS中的AD进展发病较早但并未加速。
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