Lehrstuhl für Epidemiologie, LMU München am UNIKA-T, Neusaesser Str. 47, 86156, Augsburg, Germany.
Wien Klin Wochenschr. 2021 Feb;133(3-4):144-152. doi: 10.1007/s00508-020-01673-2. Epub 2020 May 20.
There is increasing evidence for an association between SB and CKD, an emerging public health problem particularly affecting old people. For this reason a systematic literature search was carried out in Embase and PubMed (Jan 2000-Dec 2018) looking for an association between SB and kidney function. A total of 10 studies met the inclusion criteria (7 cross-sectional and 3 longitudinal investigations). A sedentary lifestyle was positively and independently of several confounders related to an impaired kidney function (chronic kidney disease or decrease of glomerular filtration rate), particularly in cross-sectional studies; however, more studies are needed to further establish the current evidence and to explore the exact independent mechanisms of sedentary behavior in relation to kidney function. Due to the inconsistency of the few longitudinal studies, future investigations are required to explore if SB is prospectively associated with a higher risk of developing CKD.
越来越多的证据表明 SB 与 CKD 之间存在关联，CKD 是一个新出现的公共卫生问题，尤其影响老年人。出于这个原因，我们在 Embase 和 PubMed 中进行了系统的文献检索（2000 年 1 月至 2018 年 12 月），以寻找 SB 与肾功能之间的关联。共有 10 项研究符合纳入标准（7 项横断面研究和 3 项纵向研究）。久坐的生活方式与肾功能受损（慢性肾脏病或肾小球滤过率下降）呈正相关，且与多种混杂因素独立相关，这在横断面研究中尤为明显；然而，需要更多的研究来进一步证实目前的证据，并探讨久坐行为与肾功能之间的确切独立机制。由于少数纵向研究的结果不一致，未来的研究需要探讨 SB 是否与 CKD 的发生风险增加具有前瞻性关联。
