丹参酮：近 5 年药用化学的最新研究进展。
Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years.
机构信息
Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
出版信息
Curr Med Chem. 2021;28(14):2807-2827. doi: 10.2174/0929867327666200521124850.
Tanshinones are an important type of natural products isolated from Salvia miltiorrhiza Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water-soluble derivative of tanshinone IIa and it is used in clinical in China for treating cardiovascular diseases. In recent years, there are increasing interests in the investigation of tanshinones derivatives in various diseases. This article presents a review of the anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities and antiviral activities of tanshinones and structural modification work in recent years.
丹参酮是从丹参（Salvia miltiorrhiza Bunge）中分离得到的一类重要天然产物，具有多种生物活性。丹参酮 IIa、隐丹参酮和丹参酮 I 是三种已被广泛研究的丹参酮。特别是丹参酮 IIa 磺酸钠是丹参酮 IIa 的水溶性衍生物，在中国临床上用于治疗心血管疾病。近年来，人们对丹参酮衍生物在各种疾病中的应用研究兴趣日益浓厚。本文综述了近年来丹参酮及其结构修饰物在抗动脉粥样硬化、心脏保护、抗癌、抗菌和抗病毒活性方面的研究进展。
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