State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Curr Stem Cell Res Ther. 2021;16(1):66-73. doi: 10.2174/1574888X15666200521084417.
Due to the misuse of antibiotics, multiple drug-resistant pathogenic bacteria have increasingly emerged. This has increased the difficulty of treatment as these bacteria directly affect public health by diminishing the potency of existing antibiotics. Developing alternative therapeutic strategies is the urgent need to reduce the mortality and morbidity related to drug-resistant bacterial infections. In the past 10 to 20 years, nanomedicines have been widely studied and applied as an antibacterial agent. They have become a novel tool for fighting resistant bacteria. The most common innovative substances, metal and metal oxide nanoparticles (NPs), have been widely reported. Until recently, DNA nanostructures were used alone or functionalized with specific DNA sequences by many scholars for antimicrobial purposes which were alternatively selected as therapy for severe bacterial infections. These are a potential candidate for treatments and have a considerable role in killing antibiotic-resistant bacteria. This review involves the dimensions of multidrug resistance and the mechanism of bacteria developing drug resistance. The importance of this article is that we summarized the current study of nano-materials based on nucleic acids in antimicrobial use. Meanwhile, the current progress and the present obstacles for their antibacterial and therapeutic use and special function of stem cells in this field are also discussed.
由于抗生素的滥用，越来越多的多药耐药病原菌出现。这些细菌通过降低现有抗生素的效力直接影响公众健康，增加了治疗的难度。开发替代治疗策略是减少与耐药细菌感染相关的死亡率和发病率的迫切需要。在过去的 10 到 20 年中，纳米医学已被广泛研究和应用作为一种抗菌剂。它们已成为对抗耐药细菌的一种新工具。最常见的创新物质是金属和金属氧化物纳米颗粒（NPs），已被广泛报道。直到最近，许多学者才将 DNA 纳米结构单独使用或通过特定的 DNA 序列功能化，用于抗菌目的，这些 DNA 纳米结构可作为严重细菌感染的治疗方法。这些是治疗的潜在候选药物，在杀死抗生素耐药细菌方面发挥着重要作用。本文综述了多药耐药的维度和细菌产生耐药性的机制。本文的重要性在于总结了基于核酸的纳米材料在抗菌应用方面的最新研究进展。同时，还讨论了它们在抗菌和治疗用途方面的当前进展和目前障碍以及干细胞在该领域的特殊功能。
