Xing Zhenyu, Guo Jiusi, Wu Zihe, He Chao, Wang Liyun, Bai Mingru, Liu Xikui, Zhu Bihui, Guan Qiuyue, Cheng Chong
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Department of Orthodontics, Department of Endodontics, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Small. 2023 Dec;19(50):e2303594. doi: 10.1002/smll.202303594. Epub 2023 Aug 25.
Bacterial infection continues to be an increasing global health problem with the most widely accepted treatment paradigms restricted to antibiotics. However, the overuse and misuse of antibiotics have triggered multidrug resistance of bacteria, frustrating therapeutic outcomes, and leading to higher mortality rates. Even worse, the tendency of bacteria to form biofilms on living and nonliving surfaces further increases the difficulty in confronting bacteria because the extracellular matrix can act as a robust barrier to prevent the penetration of antibiotics and resist environmental damage. As a result, the inability to eliminate bacteria and biofilms often leads to persistent infection, implant failure, and device damage. Therefore, it is of paramount importance to develop alternative antimicrobial agents while avoiding the generation of bacterial resistance to prevent the large-scale growth of bacterial resistance. In recent years, nano-antibacterial materials have played a vital role in the antibacterial field because of their excellent physical and chemical properties. This review focuses on new physicochemical antibacterial strategies and versatile antibacterial nanomaterials, especially the mechanism and types of 2D antibacterial nanomaterials. In addition, this advanced review provides guidance on the development direction of antibiotic-free disinfections in the antibacterial field in the future.
细菌感染仍然是一个日益严重的全球健康问题，目前最广泛接受的治疗模式局限于抗生素。然而，抗生素的过度使用和滥用引发了细菌的多重耐药性，使治疗效果受挫，并导致更高的死亡率。更糟糕的是，细菌在生物和非生物表面形成生物膜的趋势进一步增加了对抗细菌的难度，因为细胞外基质可以作为一个强大的屏障，阻止抗生素的渗透并抵抗环境破坏。因此，无法消除细菌和生物膜往往会导致持续感染、植入失败和器械损坏。所以，开发替代抗菌剂同时避免产生细菌耐药性以防止细菌耐药性大规模增长至关重要。近年来，纳米抗菌材料因其优异的物理和化学性质在抗菌领域发挥了至关重要的作用。本综述重点关注新的物理化学抗菌策略和多功能抗菌纳米材料，特别是二维抗菌纳米材料的作用机制和类型。此外，这篇前沿综述为未来抗菌领域无抗生素消毒的发展方向提供了指导。
