十七种抗菌化合物对七种分枝杆菌的体外活性。

In-vitro activity of seventeen antimicrobial compounds against seven species of mycobacteria.

作者信息

Collins C H, Uttley A H

机构信息

Public Health Laboratory, Dulwich Hospital, London, UK.

出版信息

J Antimicrob Chemother. 1988 Dec;22(6):857-61. doi: 10.1093/jac/22.6.857.

DOI:10.1093/jac/22.6.857

PMID:3243734

Abstract

Within attainable serum concentrations, quinolones, especially ciprofloxacin, inhibited strains of Mycobacterium tuberculosis, M. xenopi, M. kansasii, M. fortuitum and M. marinum; vancomycin inhibited M. tuberculosis, the M. avium-intracellulare-scrofulaceum complex. M. kansasii, M. xenopi and M. chelonei; erythromycin was active against M. kansasii, M. xenopi and M. fortuitum, minocycline against M. kansasii and M. marinum and netilmicin and cefuroxime against M. xenopi. Aztreonam showed some activity against M. tuberculosis but little or no effect was shown by five cephalosporins or imipenem.

摘要

在可达到的血清浓度范围内，喹诺酮类药物，尤其是环丙沙星，对结核分枝杆菌、偶发分枝杆菌、堪萨斯分枝杆菌、龟分枝杆菌和海分枝杆菌菌株具有抑制作用；万古霉素对结核分枝杆菌、鸟分枝杆菌-胞内分枝杆菌-瘰疬分枝杆菌复合群、堪萨斯分枝杆菌、偶发分枝杆菌和龟分枝杆菌有抑制作用；红霉素对堪萨斯分枝杆菌、偶发分枝杆菌和龟分枝杆菌有活性，米诺环素对堪萨斯分枝杆菌和海分枝杆菌有活性，奈替米星和头孢呋辛对偶发分枝杆菌有活性。氨曲南对结核分枝杆菌有一定活性，但五种头孢菌素或亚胺培南几乎没有效果或没有效果。