Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.
Echocardiography. 2020 Jun;37(6):928-929. doi: 10.1111/echo.14704. Epub 2020 May 21.
A 70-year-old asymptomatic male who had undergone a right nephrectomy for renal pelvic cancer was referred to us with a thrombus in the ascending aorta detected by contrast-enhanced computed tomography after chemotherapy with gemcitabine/cisplatin. Transesophageal echocardiography revealed a 4-cm mobile mural thrombus in the ascending aorta. An emergency thoracotomy for planned aortic root replacement was performed, but the intraoperative epi-aortic ultrasound indicated that the thrombus had disappeared, and it showed prominent spontaneous-echo contrast (SEC) in the ascending aorta. We speculate that vascular endothelium damage due to the cisplatin-based chemotherapy induced the thrombus and SEC in the ascending aorta.
一位 70 岁无症状男性因肾盂癌接受右肾切除术，在接受吉西他滨/顺铂化疗后，通过增强计算机断层扫描发现升主动脉内有血栓。经食管超声心动图显示升主动脉内有一个 4 厘米大小的活动壁血栓。计划进行主动脉根部置换的急诊开胸手术，但术中主动脉外超声提示血栓已经消失，升主动脉内出现明显的自发性回声对比（SEC）。我们推测基于顺铂的化疗引起的血管内皮损伤导致了升主动脉内的血栓和 SEC。
