Department of Neurology and Stroke Medicine, Tokyo Metropolitan Tama Medical Center, Japan.
Intern Med. 2021 Mar 15;60(6):945-951. doi: 10.2169/internalmedicine.5761-20. Epub 2020 Oct 21.
A 59-year-old woman with small-cell lung carcinoma achieved tumor disappearance after cisplatin-based chemotherapy (CBC) and radiation treatment but subsequently experienced right hemiparesis and aphasia. Brain magnetic resonance imaging revealed a left middle cerebral artery territory acute infarction and left internal carotid artery occlusion. Ultrasonography revealed a mobile thrombus in the left common and internal carotid arteries, and contrast computed tomography revealed a mural thrombus in the ascending aorta. Based on these findings, embolic stroke due to aortic mural thrombus following CBC was diagnosed. Aortic mural thrombus is a rare complication of CBC but carries a risk of embolic stroke.
一位 59 岁女性患有小细胞肺癌，在接受顺铂为基础的化疗（CBC）和放射治疗后肿瘤消失，但随后出现右侧偏瘫和失语。脑部磁共振成像显示左侧大脑中动脉区域急性梗死和左侧颈内动脉闭塞。超声显示左侧颈总动脉和颈内动脉有活动血栓，对比计算机断层扫描显示升主动脉有壁血栓。根据这些发现，诊断为 CBC 后主动脉壁血栓引起的栓塞性中风。CBC 后主动脉壁血栓是一种罕见的并发症，但有发生栓塞性中风的风险。
