Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Oral Dis. 2021 Jul;27(5):1106-1114. doi: 10.1111/odi.13435. Epub 2020 Jul 13.
Opioid receptors are widely distributed in the central and peripheral nervous systems and non-neuronal tissues. Numerous researchers have noted the pivotal role of peripheral opioid receptors (PORs) in analgesia. Accumulating evidence has shown the existence of PORs in the trigeminal nerve system, indicating that PORs may be involved in the modulation of orofacial pain. In this review, we summarise the recent evidence for the role of PORs in orofacial pain and discuss the possible cellular mechanisms.
阿片受体广泛分布于中枢和外周神经系统以及非神经组织中。众多研究人员注意到外周阿片受体（POR）在镇痛中的关键作用。越来越多的证据表明 POR 存在于三叉神经系统中，这表明 POR 可能参与了口面部疼痛的调节。在这篇综述中，我们总结了 POR 参与口面部疼痛的最新证据，并讨论了可能的细胞机制。
