Department of Urology, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Clinical Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Cells. 2020 May 19;9(5):1250. doi: 10.3390/cells9051250.
Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. These therapeutic interventions exhibit significant impact in providing relief to patients; however, due to their associated adverse effects and lack of long-term efficacy, newer modalities such as regenerative therapeutics have gained attention due to their safe and prolonged efficacy. Stem cells and platelet-derived biomaterials contained in platelet-rich plasma (PRP) are thriving as some of the major therapeutic regenerative agents. In recent years, various preclinical and clinical studies have evaluated the individual, as well as combined of stem cells and PRP to restore erectile function. Being rich in growth factors, chemokines, and angiogenic factors, both stem cells and PRP play a crucial role in regenerating nerve cells, myelination of axons, homing and migration of progenitor cells, and anti-fibrosis and anti-apoptosis of damaged cavernous nerve in corporal tissues. Further, platelet-derived biomaterials have been proven to be a biological supplement for enhancing the proliferative and differentiation potential of stem cells towards neurogenic fate. Therefore, this article comprehensively analyzes the progresses of these regenerative therapies for ED.
勃起功能障碍（ED）是指无法获得或维持足够的阴茎勃起以进行成功的阴道性交，从而导致性和关系不满意。为了治疗 ED，过去已经开发了各种手术和非手术方法来恢复勃起功能。这些治疗干预措施在为患者提供缓解方面具有显著的影响；然而，由于它们存在相关的不良反应和缺乏长期疗效，新型治疗方法，如再生治疗，因其安全和持久的疗效而受到关注。富含血小板的血浆（PRP）中的干细胞和血小板衍生生物材料作为一些主要的治疗性再生剂而备受关注。近年来，各种临床前和临床研究已经评估了干细胞和 PRP 单独或联合使用以恢复勃起功能。由于富含生长因子、趋化因子和血管生成因子，干细胞和 PRP 在再生神经细胞、轴突髓鞘形成、祖细胞归巢和迁移以及损伤的海绵体神经中的抗纤维化和抗细胞凋亡方面发挥着至关重要的作用。此外，血小板衍生的生物材料已被证明是一种生物补充剂，可增强干细胞向神经发生命运的增殖和分化潜力。因此，本文全面分析了这些再生疗法在 ED 中的进展。
