美国从不吸烟者的肺癌死亡率：利用全国代表性数据估计与吸烟有关的死亡率。

Lung cancer mortality among never-smokers in the United States: estimating smoking-attributable mortality with nationally representative data.

机构信息

Department of Sociology, University of Memphis, Memphis, TN.

Department of Sociology, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill.

出版信息

Ann Epidemiol. 2020 May;45:5-11. doi: 10.1016/j.annepidem.2020.03.008. Epub 2020 Apr 3.

DOI:10.1016/j.annepidem.2020.03.008

PMID:32439149

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7250145/

Abstract

PURPOSE

Lung cancer mortality among never-smokers is an often overlooked yet important cause of adult mortality. Moreover, indirect approaches for estimating smoking-attributable mortality use never-smoker lung cancer death rates to approximate smoking burden. To date, though, most studies using indirect approaches import rates from the Cancer Prevention Study II (CPS-II), which is not representative of the U.S.

METHODS

We use the nationally representative 1985-2015 National Health Interview Survey-Linked Mortality Files (NHIS-LMF) to calculate lung cancer death rates among never-smokers aged 50 years or older. We then import rates from NHIS-LMF and CPS-II into the Preston-Glei-Wilmoth indirect method to determine whether smoking-attributable fractions differ.

RESULTS

Never-smokers account for 16% of U.S. lung cancer deaths among women and 11% among men. Lung cancer death rates among never-smokers are higher in NHIS-LMF than CPS-II for several age groups. Smoking-attributable fractions of mortality are slightly lower with NHIS-LMF rates (19% of male deaths and 16% of female deaths) than with CPS-II rates (21% of male deaths and 17% of female deaths).

CONCLUSIONS

Fractions based on nonrepresentative CPS-II data may modestly overestimate smoking-attributable mortality. Thus, indirect methods should use never-smoker lung cancer death rates from such nationally representative datasets as NHIS-LMF.

摘要

目的

从不吸烟者的肺癌死亡率是成人死亡率中一个经常被忽视但很重要的原因。此外，用于估计与吸烟有关的死亡率的间接方法使用从不吸烟者的肺癌死亡率来近似吸烟负担。然而，迄今为止，大多数使用间接方法的研究都从癌症预防研究 II（CPS-II）中导入了数据，而这些数据并不能代表美国的情况。

方法

我们使用具有全国代表性的 1985-2015 年全国健康访谈调查-死亡档案（NHIS-LMF）来计算年龄在 50 岁或以上的从不吸烟者的肺癌死亡率。然后，我们将 NHIS-LMF 和 CPS-II 的数据导入普雷斯顿-盖尔-威尔莫特间接法，以确定吸烟归因分数是否存在差异。

结果

从不吸烟者占美国女性肺癌死亡人数的 16%，男性的这一比例为 11%。在几个年龄组中，NHIS-LMF 中的从不吸烟者的肺癌死亡率高于 CPS-II。使用 NHIS-LMF 数据（男性死亡人数的 19%和女性死亡人数的 16%）计算得出的死亡率归因分数略低于使用 CPS-II 数据（男性死亡人数的 21%和女性死亡人数的 17%）。