5-氟尿嘧啶与呋氟尿嘧啶在大肠杆菌中的作用比较。
Comparison of the actions of 5-fluorouracil and ftorafur in Escherichia coli.
作者信息
Saunders P P, Chao L Y
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):451-4. doi: 10.1128/AAC.11.3.451.
Abstract
The actions of 5-fluorouracil (FU) and Ftorafur (NCS 148958) were compared in Escherichia coli B3 to determine if Ftorafur can act in ways other than through the production of FU. Very high concentrations of Ftorafur relative to FU were necessary to achieve a comparable inhibition of cell growth. Inhibition by both agents could be reversed by uracil. An FU-resistant strain and an Ftorafur-resistant strain were isolated and found to be cross-resistant to Ftorafur and FU, respectively.
摘要
在大肠杆菌B3中比较了5-氟尿嘧啶（FU）和呋氟尿嘧啶（NCS 148958）的作用，以确定呋氟尿嘧啶是否能通过除产生FU之外的其他方式发挥作用。相对于FU，需要非常高浓度的呋氟尿嘧啶才能实现对细胞生长的类似抑制。两种药物的抑制作用都可被尿嘧啶逆转。分离出一株FU抗性菌株和一株呋氟尿嘧啶抗性菌株，发现它们分别对呋氟尿嘧啶和FU具有交叉抗性。
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