Gleiter C H, Antonin K H, Schoenleber W, Bieck P R
Human Pharmacology Institute, Ciba-Geigy GmbH Tuebingen, FRG.
J Clin Pharmacol. 1988 Dec;28(12):1123-7. doi: 10.1002/j.1552-4604.1988.tb05728.x.
In a placebo-controlled, randomized, double-blind cross-over study in 12 healthy volunteers the effect of acute alcohol intake during treatment with transdermally administered scopolamine (TTS-scopolamine) was investigated. One group of six subjects reached maximal blood alcohol concentrations (BAC) of 80 mg/dL and another group of six subjects a BAC of 130 mg/dL. There was no significant potentiation of alcohol effects on critical flicker fusion frequency by TTS-scopolamine. Sensorimotor function (choice reaction task) was also not significantly more influence by the combination. There was no effect of scopolamine on the elimination of alcohol. The urinary excretion of scopolamine was not influenced by oral intake of alcohol. TTS-scopolamine caused only minor side effects in a few volunteers, such as dry mouth (2 of 12) and blurred vision (1 of 12).
在一项针对12名健康志愿者的安慰剂对照、随机、双盲交叉研究中，研究了经皮给予东莨菪碱（透皮东莨菪碱，TTS-东莨菪碱）治疗期间急性饮酒的影响。一组6名受试者的血液酒精浓度（BAC）达到80mg/dL，另一组6名受试者的BAC达到130mg/dL。透皮东莨菪碱对酒精对临界闪烁融合频率的影响没有显著增强作用。感觉运动功能（选择反应任务）也没有受到该组合的显著更大影响。东莨菪碱对酒精的消除没有影响。口服酒精对东莨菪碱的尿排泄没有影响。透皮东莨菪碱仅在少数志愿者中引起轻微副作用，如口干（12人中有2人）和视力模糊（12人中有1人）。
