Yoshida K, Yahiro M, Ahiko K
Technical Research Institute, Snow Brand Milk Products Co., Ltd., Saitama, Japan.
J Nutr Sci Vitaminol (Tokyo). 1988 Dec;34(6):567-76. doi: 10.3177/jnsv.34.567.
The effects of the addition of varying levels of arginine (Arg), cystine (Cys), and glycine (Gly) to the bovine milk-simulated amino acid mixture on the levels of plasma and liver cholesterol were investigated in rats. The diets containing a high amount of Cys lowered significantly the level of plasma cholesterol as the amount of Cys in diets increased. The serum high density lipoprotein (HDL)-cholesterol level and fecal excretion of acidic steroids were higher in rats fed the Cys diets than in those fed the Arg and Gly diets. No differences, however, was observed in the content of liver cholesterol. Liver triglyceride contents elevated significantly on feeding the Arg and Cys diets. Furthermore, liver phospholipid contents elevated significantly on feeding the Arg diet but lowered on feeding the Cys diet. Therefore, these results indicated that the feeding of a high amount of Cys lowers the plasma cholesterol levels as the result of the enhanced conversion of cholesterol to bile acids.
在大鼠中研究了向模拟牛乳的氨基酸混合物中添加不同水平的精氨酸（Arg）、胱氨酸（Cys）和甘氨酸（Gly）对血浆和肝脏胆固醇水平的影响。随着日粮中胱氨酸含量的增加，含有大量胱氨酸的日粮显著降低了血浆胆固醇水平。喂食含胱氨酸日粮的大鼠血清高密度脂蛋白（HDL）胆固醇水平和酸性类固醇的粪便排泄量高于喂食精氨酸和甘氨酸日粮的大鼠。然而，肝脏胆固醇含量未观察到差异。喂食精氨酸和胱氨酸日粮时肝脏甘油三酯含量显著升高。此外，喂食精氨酸日粮时肝脏磷脂含量显著升高，而喂食胱氨酸日粮时则降低。因此，这些结果表明，喂食大量胱氨酸可降低血浆胆固醇水平，这是胆固醇向胆汁酸转化增强的结果。
