Sugiyama K, Mizuno M, Muramatsu K
J Nutr Sci Vitaminol (Tokyo). 1986 Dec;32(6):623-33. doi: 10.3177/jnsv.32.623.
The effect of individual amino acids added to a cholesterol containing casein diet on the plasma cholesterol level of rats was systematically investigated with objective of confirming the possibility that specific amino acids are responsible for the regulation of plasma cholesterol level by dietary proteins. Half the amino acids tested were effective to some degree in influencing the plasma cholesterol level when amino acids were added singly to the diet at a 5% level. However, only sulfur containing amino acids had significant effects when added to the diet at a 1% level; Met enhanced and Cys reduced the plasma cholesterol level. In addition, the results of an experiment with amino acid mixture diets with different Met, Cys, and/or Gly contents indicated the importance of sulfur amino acids and also of Gly in plasma cholesterol regulation. The results obtained here support the notion that the plasma cholesterol level of rats can be influenced by specific amino acids or amino acid compositions of dietary proteins, at least under the experimental conditions used.
系统研究了在含胆固醇的酪蛋白饮食中添加单个氨基酸对大鼠血浆胆固醇水平的影响，目的是确认特定氨基酸是否负责通过膳食蛋白质调节血浆胆固醇水平。当以5%的水平将氨基酸单独添加到饮食中时，所测试的一半氨基酸在一定程度上对血浆胆固醇水平有影响。然而，当以1%的水平添加到饮食中时，只有含硫氨基酸有显著影响；蛋氨酸提高而半胱氨酸降低血浆胆固醇水平。此外，对不同蛋氨酸、半胱氨酸和/或甘氨酸含量的氨基酸混合饮食的实验结果表明，含硫氨基酸以及甘氨酸在血浆胆固醇调节中很重要。此处获得的结果支持这样一种观点，即至少在所使用的实验条件下，大鼠的血浆胆固醇水平可受膳食蛋白质中的特定氨基酸或氨基酸组成影响。
