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霍奇金淋巴瘤诊断前的胆管消失综合征

Vanishing Bile Duct Syndrome Preceding the Diagnosis of Hodgkin Lymphoma.

作者信息

Anugwom Chimaobi, Goetz Grete, Hassan Mohamed

机构信息

Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN.

出版信息

ACG Case Rep J. 2020 Mar 2;7(2):e00336. doi: 10.14309/crj.0000000000000336. eCollection 2020 Feb.

DOI:10.14309/crj.0000000000000336
PMID:32440528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7209801/
Abstract

Vanishing bile duct syndrome is an acquired liver disease characterized by the progressive destruction and loss of intrahepatic bile ducts. It usually signifies end-stage cholestatic liver disease and is characterized by ductopenia on liver biopsy specimen. We present a case of vanishing bile duct syndrome as the presenting symptom in a patient with Hodgkin lymphoma with subsequent improvement after adequate treatment of the lymphoma.

摘要

消失胆管综合征是一种获得性肝脏疾病,其特征为肝内胆管进行性破坏和丧失。它通常预示着终末期胆汁淤积性肝病,肝活检标本显示胆管减少是其特征。我们报告一例以消失胆管综合征为首发症状的霍奇金淋巴瘤患者,淋巴瘤得到充分治疗后病情随后有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f94e/7209801/a12d0537e5c8/ac9-7-e00336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f94e/7209801/51bbcae70042/ac9-7-e00336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f94e/7209801/a12d0537e5c8/ac9-7-e00336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f94e/7209801/51bbcae70042/ac9-7-e00336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f94e/7209801/a12d0537e5c8/ac9-7-e00336-g002.jpg

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引用本文的文献

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Front Immunol. 2025 May 21;16:1561110. doi: 10.3389/fimmu.2025.1561110. eCollection 2025.
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3
Hodgkin lymphoma associated vanishing bile duct syndrome treated successfully with a brentuximab based regimen.

本文引用的文献

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Vanishing Bile Duct Syndrome in a Patient with Uterine Cancer and Paraneoplastic Systemic Sclerosis.一名子宫癌合并副肿瘤性系统性硬化症患者的肝内胆管消失综合征
ACG Case Rep J. 2018 Dec 19;5:e95. doi: 10.14309/crj.2018.95. eCollection 2018.
2
Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review.霍奇金淋巴瘤中的胆管消失综合征:一例报告及文献复习
World J Gastroenterol. 2017 Jan 14;23(2):366-372. doi: 10.3748/wjg.v23.i2.366.
3
Identification of Bile Duct Paucity in Alagille Syndrome: Using CK7 and EMA Immunohistochemistry as a Reliable Panel for Accurate Diagnosis.
成功用博来霉素、依托泊苷、多柔比星、长春新碱和达卡巴嗪方案治疗霍奇金淋巴瘤相关的进行性肝内胆汁淤积症。
BMJ Case Rep. 2023 Nov 21;16(11):e257211. doi: 10.1136/bcr-2023-257211.
4
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SAGE Open Med Case Rep. 2023 Nov 9;11:2050313X231208968. doi: 10.1177/2050313X231208968. eCollection 2023.
5
Drug-induced Liver Injury Considered Steroid-resistant and Histologically Diagnosed with Vanishing Bile Duct Syndrome.药物性肝损伤,考虑为类固醇抵抗且组织学诊断为消失的胆管综合征。
Intern Med. 2024 Jun 15;63(12):1719-1723. doi: 10.2169/internalmedicine.2427-23. Epub 2023 Nov 13.
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Vanishing bile duct syndrome-related jaundice as the first presentation of Hodgkin lymphoma.以消失性胆管综合征相关黄疸为首发表现的霍奇金淋巴瘤
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7
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In Vivo. 2021 Jul-Aug;35(4):1951-1957. doi: 10.21873/invivo.12462.
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Pediatr Dev Pathol. 2016 Jan-Feb;19(1):47-50. doi: 10.2350/15-05-1628-OA.1. Epub 2015 Sep 14.
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