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危险药物暴露:一项前瞻性、多地点研究中肿瘤科护士在门诊环境中暴露情况的病例报告分析。

Hazardous Drug Exposure: Case Report Analysis From a Prospective, Multisite Study of Oncology Nurses' Exposure in Ambulatory Settings.

机构信息

University of Michigan School of Nursing and University of Michigan Rogel Cancer Center.

Northwestern University.

出版信息

Clin J Oncol Nurs. 2020 Jun 1;24(3):249-255. doi: 10.1188/20.CJON.249-255.

DOI:10.1188/20.CJON.249-255
PMID:32441682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7271974/
Abstract

BACKGROUND

Hazardous drug exposure is an occupational health hazard to oncology nurses. Sparse data are available regarding the frequency and characteristics of hazardous drug spills.

OBJECTIVES

This article aims to describe nurses' hazardous drug exposures and use of personal protective equipment during drug spills.

METHODS

The Drug Exposure Feedback and Education for Nurses' Safety study launched in March 2015. When drug spills occurred, consented RNs administering chemotherapy in ambulatory infusion settings completed brief questionnaires. Descriptive statistics were used to summarize equipment use and spill events.

FINDINGS

Spills were common, despite the use of closed-system transfer devices. Over two years, 51 nurses from 12 participating academic infusion centers reported 61 unique spills. Spills commonly involved highly toxic drugs. Personal protective equipment use during drug spills was suboptimal. These foundational data reveal gaps in clinical practice.

摘要

背景

肿瘤护士在工作中会接触到有害药物,这对他们的健康是一种危害。目前,有关有害药物溢出的频率和特征的数据十分有限。

目的

本研究旨在描述护士在药物溢出时的有害药物暴露情况和个人防护设备的使用情况。

方法

“药物暴露反馈和护士安全教育研究”于 2015 年 3 月启动。当发生药物溢出时,正在门诊输液环境中进行化疗的同意参与的注册护士完成简短的问卷。使用描述性统计来总结设备使用和溢出事件。

结果

尽管使用了密闭式传输装置,但溢出仍很常见。在两年的时间里,来自 12 个参与学术输液中心的 51 名护士报告了 61 个独特的溢出事件。溢出通常涉及高毒性药物。药物溢出时个人防护设备的使用并不理想。这些基础数据揭示了临床实践中的差距。

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本文引用的文献

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NTP monograph on the systematic review of occupational exposure to cancer chemotherapy agents and adverse health outcomes.美国国家毒理学计划关于职业接触癌症化疗药物及不良健康后果的系统综述专论。
NTP Monogr. 2019 Mar(5). doi: 10.22427/NTP-MGRAPH-5.
2
Randomized Controlled Trial of an Intervention to Improve Nurses' Hazardous Drug Handling.一项旨在改善护士危险药物处理情况的干预措施的随机对照试验。
Oncol Nurs Forum. 2019 Mar 1;46(2):248-256. doi: 10.1188/19.ONF.248-256.
3
CE: Original Research: Antineoplastic Drug Administration by Pregnant and Nonpregnant Nurses: An Exploration of the Use of Protective Gloves and Gowns.CE:原始研究:孕妇和非孕妇护士的抗肿瘤药物给药:对使用防护手套和手术衣的探索。
Am J Nurs. 2019 Jan;119(1):28-35. doi: 10.1097/01.NAJ.0000552583.69729.51.
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Summary of the Workshop on the Safe Handling of Hazardous Drugs Cohosted by the National Institute for Occupational Safety and Health and the American Society of Clinical Oncology.由美国国家职业安全与健康研究所和美国临床肿瘤学会联合主办的危险药物安全处理研讨会总结
J Oncol Pract. 2017 Mar;13(3):199-205. doi: 10.1200/JOP.2016.017384. Epub 2017 Feb 21.
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Registry-Based Prospective, Active Surveillance of Medical-Device Safety.基于注册的医疗设备安全性前瞻性主动监测
N Engl J Med. 2017 Feb 9;376(6):526-535. doi: 10.1056/NEJMoa1516333. Epub 2017 Jan 25.
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Personal Protective Equipment Use and Hazardous Drug Spills Among Ambulatory Oncology Nurses.门诊肿瘤护士的个人防护装备使用情况及危险药物溢出情况
Oncol Nurs Forum. 2017 Jan 6;44(1):60-65. doi: 10.1188/17.ONF.60-65.
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