Lord J W, Rossi G, Daliana M
Ann Surg. 1977 Jun;185(6):634-41. doi: 10.1097/00000658-197706000-00004.
Intraoperative antibiotic wound lavage has been used in all arterial reconstructive procedures for the past 7 years and reduced the incidence of early and late postoperative infections from 1.5% in 400 operations prior to 1969 to 0.23% (one post-hospital) in 434 patients operated since that date. In 226 consecutive clean major general surgical procedures since June 1971 there has been no early or late wound infections following intraoperative antibiotic wound lavage in contrast to an infection rate of 1.5% in 185 operations prior to that date. A double blind study of 200 patients undergoing operations for varicose veins was carried out as follows: The wounds of alternate patients were irrigated either with normal saline or with antibiotic solution. There were no gross (grade II) postoperative wound infections. Minor skin changes were noted in 93 of 632 incisions in the saline group and only 49 of 608 incisions irrigated with antibiotic solution (P less than 0.001). In clean operations without antibiotic wound lavage there was a 0.73% rate of in-hospital wound infections in 685 patients in contrast to a zero rate in 760 patients wherein intraoperative wound lavage was carried out throughout the operative procedure.
在过去7年中，术中抗生素伤口灌洗已应用于所有动脉重建手术，术后早期和晚期感染发生率从1969年之前400例手术中的1.5%降至自那时起434例手术中的0.23%（1例出院后感染）。自1971年6月起的226例连续清洁大外科手术中，术中抗生素伤口灌洗后未发生早期或晚期伤口感染，而在此之前的185例手术中感染率为1.5%。对200例接受静脉曲张手术的患者进行了一项双盲研究，具体如下：交替患者的伤口分别用生理盐水或抗生素溶液冲洗。未发生严重（Ⅱ级）术后伤口感染。生理盐水组632处切口中有93处出现轻微皮肤改变，而用抗生素溶液冲洗的608处切口中仅有49处出现轻微皮肤改变（P<0.001）。在未进行抗生素伤口灌洗的清洁手术中，685例患者的院内伤口感染率为0.73%，而在整个手术过程中进行术中伤口灌洗的760例患者中感染率为零。
