United States Drug Testing Laboratories, Inc., (AEB), Des Plaines, Illinois.
UCLA Counseling and Psychological Services, (NH), University of California Los Angeles, Los Angeles, California.
Alcohol Clin Exp Res. 2020 Jun;44(6):1292-1299. doi: 10.1111/acer.14339. Epub 2020 May 22.
There is increasing interest in the development of newborn screening tests to identify children at risk of fetal alcohol spectrum disorder (FASD) in order to provide these children with early intervention. Phosphatidylethanol (PEth) has emerged as a potential universal newborn screening candidate.
The aim of this report was to present the results of a study designed to compare PEth levels in 1,140 postpartum women and their newborn infants in Montevideo, Uruguay, and Sao Paulo, Brazil. Self-report alcohol use during pregnancy data was collected, along with both maternal and newborn dried blood spot samples for PEth analysis.
The average age and parity of the women in the sample were 26 years of age and 2.3 pregnancies. For the Uruguay sample (n = 611), 45.8% of postpartum women had PEth levels ≥ 8 ng/ml with a mean positive PEth of 43.6 ng/ml. In contrast, 86.8% of the newborns had PEth levels ≥ 8 ng/ml, with a mean positive PEth of 77.4 ng/ml. For the Brazil sample (n = 529), 33.2% of women had PEth levels ≥ 8 ng/ml with a mean positive PEth of 31 ng/ml. In contrast, 76.9% of the Brazil newborns had PEth levels ≥ 8 ng/ml and 43.9% with a mean positive PEth of 61.1 ng/ml. PEth levels were significantly higher in newborns compared with their postpartum mothers in both the Uruguay and Brazil samples. Self-reported third-trimester alcohol was 6% in the Uruguay sample and 9.1% in the Brazil sample compared with positive maternal PEth levels in 45.8% and 33.2%, respectively.
Clinicians may want to consider newborn PEth screening in high-risk populations where prenatal alcohol use is common. The mechanism underlying significantly higher PEth levels in newborns compared with their mothers is not known.
人们越来越关注开发新生儿筛查测试，以识别患有胎儿酒精谱系障碍（FASD）风险的儿童，从而为这些儿童提供早期干预。磷酯酰乙醇（PEth）已成为一种潜在的通用新生儿筛查候选物。
本报告旨在介绍一项旨在比较乌拉圭蒙得维的亚和巴西圣保罗的 1140 名产后妇女及其新生儿的 PEth 水平的研究结果。收集了自我报告的孕期饮酒数据，以及用于 PEth 分析的母婴干血斑样本。
样本中妇女的平均年龄和孕次分别为 26 岁和 2.3 次妊娠。对于乌拉圭样本（n=611），45.8%的产后妇女的 PEth 水平≥8ng/ml，平均阳性 PEth 为 43.6ng/ml。相比之下，86.8%的新生儿的 PEth 水平≥8ng/ml，平均阳性 PEth 为 77.4ng/ml。对于巴西样本（n=529），33.2%的妇女的 PEth 水平≥8ng/ml，平均阳性 PEth 为 31ng/ml。相比之下，76.9%的巴西新生儿的 PEth 水平≥8ng/ml，43.9%的新生儿的平均阳性 PEth 为 61.1ng/ml。在乌拉圭和巴西样本中，与产后母亲相比，新生儿的 PEth 水平明显更高。在乌拉圭样本中，自我报告的孕晚期饮酒率为 6%，在巴西样本中为 9.1%，而阳性母体 PEth 水平分别为 45.8%和 33.2%。
在产前饮酒常见的高危人群中，临床医生可能需要考虑新生儿 PEth 筛查。与母亲相比，新生儿的 PEth 水平明显更高的机制尚不清楚。
