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30 例儿童新型冠状病毒肺炎(COVID-19)的 CT 特征。

CT Features of Coronavirus Disease (COVID-19) in 30 Pediatric Patients.

机构信息

Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY.

Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

出版信息

AJR Am J Roentgenol. 2020 Dec;215(6):1303-1311. doi: 10.2214/AJR.20.23145. Epub 2020 May 22.

Abstract

The purpose of this study is to characterize the CT findings of 30 children from mainland China who had laboratory-confirmed coronavirus disease (COVID-19). Although recent American College of Radiology recommendations assert that CT should not be used as a screening or diagnostic tool for patients with suspected COVID-19, radiologists should be familiar with the imaging appearance of this disease to identify its presence in patients undergoing CT for other reasons. We retrospectively reviewed the CT findings and clinical symptoms of 30 pediatric patients with laboratory-confirmed COVID-19 who were seen at six centers in China from January 23, 2020, to February 8, 2020. Patient age ranged from 10 months to 18 years. Patients older than 18 years of age or those without chest CT examinations were excluded. Two cardiothoracic radiologists and a cardiothoracic imaging fellow characterized and scored the extent of lung involvement. Cohen kappa coefficient was used to calculate interobserver agreement between the readers. Among children, CT findings were often negative (77%). Positive CT findings seen in children included ground-glass opacities with a peripheral lung distribution, a crazy paving pattern, and the halo and reverse halo signs. There was a correlation between increasing age and increasing severity of findings, consistent with reported symptomatology in children. Eleven of 30 patients (37%) underwent follow-up chest CT, with 10 of 11 examinations (91%) showing no change, raising questions about the utility of CT in the diagnosis and management of COVID-19 in children. The present study describes the chest CT findings encountered in children with COVID-19 and questions the utility of CT in the diagnosis and management of pediatric patients.

摘要

本研究旨在描述 30 名中国大陆实验室确诊的 2019 冠状病毒病(COVID-19)患儿的 CT 表现。尽管最近美国放射学院的建议指出,CT 不应用于疑似 COVID-19 患者的筛查或诊断工具,但放射科医生应该熟悉这种疾病的影像学表现,以便在为其他原因行 CT 检查的患者中识别出其存在。我们回顾性分析了 2020 年 1 月 23 日至 2 月 8 日期间中国 6 家中心的 30 例实验室确诊 COVID-19 患儿的 CT 表现和临床症状。患者年龄 10 个月至 18 岁。排除年龄大于 18 岁或无胸部 CT 检查的患者。两名心胸放射科医生和一名心胸影像学研究员对肺受累程度进行了特征描述和评分。采用 Cohen kappa 系数计算读者之间的观察者间一致性。在儿童中,CT 表现通常为阴性(77%)。在儿童中可见阳性 CT 表现,包括外周肺分布的磨玻璃影、铺路石征和晕征及反晕征。年龄与病变严重程度之间存在相关性,与儿童报告的症状一致。30 例患儿中有 11 例(37%)接受了胸部 CT 随访,其中 10 例(91%)无变化,这对 CT 在 COVID-19 儿童诊断和管理中的作用提出了质疑。本研究描述了 COVID-19 患儿的胸部 CT 表现,并对 CT 在儿科患者的诊断和管理中的作用提出了质疑。

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