甲氨蝶呤对清醒大鼠局部脑血流量的影响。

Effect of methotrexate on local cerebral blood flow in conscious rats.

作者信息

Mizusawa S, Kondoh Y, Murakami M, Nakamichi H, Sasaki H, Komatsu K, Takahashi A, Kudoh Y, Watanabe K, Ono Y

机构信息

Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita, Japan.

出版信息

Jpn J Pharmacol. 1988 Dec;48(4):499-501. doi: 10.1254/jjp.48.499.

DOI:10.1254/jjp.48.499

PMID:3244204

Abstract

The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.

摘要

采用放射自显影[14C] - 碘代安替比林法，在正常清醒大鼠中研究了甲氨蝶呤（MTX）对局部脑血流量（I - CBF）的影响。与注射生理盐水的对照组相比，给予MTX（100mg或200mg/只）的大鼠I - CBF降低了30 - 57%，但未观察到剂量依赖性效应。文中讨论了MTX降低I - CBF的机制。