Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
Sleep. 2020 Nov 12;43(11). doi: 10.1093/sleep/zsaa099.
Type-1 narcolepsy is a severe neurological disorder with distinct characteristic of loss of hypocretin neurotransmitter. Genetic analysis in type-1 narcolepsy have revealed a unique signal pointing toward autoimmune, rather than psychiatric origin. While type-1 narcolepsy has been intensively studied, the other subtypes of hypersomnolence, narcolepsy, and hypersomnia are less thoroughly understood. This review summarizes the latest breakthroughs in the field in narcolepsy. The goal of this article is to help the reader to understand better the risk from genetic factors and their interplay with immune, genetic, and epidemiological aspects in narcolepsy.
1 型发作性睡病是一种严重的神经疾病，其特征是下丘脑分泌素神经递质缺失。1 型发作性睡病的遗传分析显示出一种独特的信号，指向自身免疫，而不是精神起源。虽然 1 型发作性睡病已得到深入研究，但其他类型的过度嗜睡、发作性睡病和嗜睡症的了解还不够透彻。本文综述了发作性睡病领域的最新突破。本文的目的是帮助读者更好地理解遗传因素的风险及其与发作性睡病的免疫、遗传和流行病学方面的相互作用。
