Radboud University, Behavioural Science Institute, Montessorilaan 3, 6525 HR, Nijmegen, the Netherlands.
Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.
Biol Psychol. 2020 Jul;154:107903. doi: 10.1016/j.biopsycho.2020.107903. Epub 2020 May 20.
Although oxytocin administration influences behavior, its effects on peripheral oxytocin concentrations are mixed and derived from studies on healthy subjects. Additionally, trauma attenuates the behavioral effects of oxytocin, but it is unknown whether it also influences its effect on peripheral circulation. This study examined whether salivary oxytocin increased after oxytocin administration and whether trauma attenuated this effect. We conducted a randomized, double-blind, placebo-controlled, within-subjects study in 100 male adolescents living in residential youth care facilities. Participants self-administered intranasally 24 IU of oxytocin and placebo (one week later) and provided a saliva sample before and 15 min after administration. Salivary oxytocin increased significantly after oxytocin administration, but this effect might be inflated by exogenous oxytocin reaching the throat. Trauma did not moderate this effect. Our findings suggest that trauma did not attenuate the effect of oxytocin administration on salivary oxytocin, but more robust methodologies are recommended to draw more solid conclusions.
虽然催产素的给药会影响行为，但它对外周催产素浓度的影响是混合的，并且源自对健康受试者的研究。此外，创伤会减弱催产素的行为效应，但尚不清楚它是否也会影响其对外周循环的影响。本研究旨在探讨催产素给药后唾液中的催产素是否增加，以及创伤是否会减弱这种效应。我们在居住在青少年住宿照料设施中的 100 名男性青少年中进行了一项随机、双盲、安慰剂对照、自身对照研究。参与者自行经鼻给予 24IU 的催产素和安慰剂（一周后），并在给药前和给药后 15 分钟提供唾液样本。催产素给药后唾液中的催产素明显增加，但这种效应可能是由于外源性催产素到达喉咙而被夸大了。创伤并没有调节这种效应。我们的研究结果表明，创伤并没有减弱催产素给药对唾液中催产素的影响，但建议采用更强大的方法来得出更可靠的结论。
