Lin Jie, Xie Guozhu, Liao Guixiang, Wang Baiyao, Yan Miaohong, Li Hui, Yuan Yawei
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Department of Radiation Oncology, Shenzhen people's Hospital, Second Clinical Medicine College of Jinan University, China.
Oncotarget. 2017 May 16;8(20):33884-33896. doi: 10.18632/oncotarget.13934.
The prognostic role of 18F-fluorodeoxyglucose positron emission tomography CT (18F-FDG PET/CT) parameters is still controversial in nasopharyngeal carcinoma patients. We sought to perform a systematic review and meta-analysis to explore the prognostic value of maximal standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) on event-free survival (EFS) and overall survival (OS) in nasopharyngeal carcinoma patients.
Fifteen studies comprising 1,938 patients were included in this study. The combined hazard ratios (HRs) for EFS were 2.63 (95%CI 1.71-4.05) for SUVmax, 2.55 (95%CI 1.49-4.35) for MTV, and 3.32 (95%CI 1.23-8.95) for TLG. The pooled HRs for OS were 2.07 (95%CI 1.54-2.79) for SUVmax, 3.86 (95%CI 1.85-8.06) for MTV, and 2.60 (95%CI 1.55-4.34) for TLG. The prognostic role of SUVmax, MTV and TLG remained similar in the sub-group analyses.
A systematic literature search was performed to identify studies which associated 18F-FDG PET/CT to clinical survival outcomes of nasopharyngeal carcinoma patients. The summarized HRs for EFS and OS were estimated by using fixed- or random-effect models according to heterogeneity between trials.
The present meta-analysis confirms that high values of SUVmax, MTV and TLG predicted a higher risk of adverse events or death in patients with nasopharyngeal carcinoma, despite clinically heterogeneous nasopharyngeal carcinoma patients and the various methods adopted between these studies.
18F-氟脱氧葡萄糖正电子发射断层扫描CT（18F-FDG PET/CT）参数在鼻咽癌患者中的预后作用仍存在争议。我们旨在进行一项系统评价和荟萃分析，以探讨最大标准化摄取值（SUVmax）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）对鼻咽癌患者无事件生存期（EFS）和总生存期（OS）的预后价值。
本研究纳入了15项研究，共1938例患者。SUVmax、MTV和TLG的EFS合并风险比（HR）分别为2.63（95%CI 1.71-4.05）、2.55（95%CI 1.49-4.35）和3.32（95%CI 1.23-8.95）。SUVmax、MTV和TLG的OS合并HR分别为2.07（95%CI 1.54-2.79）、3.86（95%CI 1.85-8.06）和2.60（95%CI 1.55-4.34）。在亚组分析中，SUVmax、MTV和TLG的预后作用仍然相似。
进行系统的文献检索，以确定将18F-FDG PET/CT与鼻咽癌患者临床生存结局相关联的研究。根据各试验之间的异质性，使用固定效应或随机效应模型估计EFS和OS的汇总HR。
本荟萃分析证实，尽管鼻咽癌患者临床情况各异且这些研究采用的方法不同，但SUVmax、MTV和TLG值较高预示着鼻咽癌患者发生不良事件或死亡的风险较高。
