正电子发射断层扫描/计算机断层扫描的最大标准摄取值、代谢肿瘤体积和总病变糖酵解在鼻咽癌患者中的预后价值：一项系统评价和荟萃分析。
Prognostic value of maximum standard uptake value, metabolic tumor volume, and total lesion glycolysis of positron emission tomography/computed tomography in patients with nasopharyngeal carcinoma: A systematic review and meta-analysis.
作者信息
Li Qingfang, Zhang Jing, Cheng Wei, Zhu Chenjing, Chen Linyan, Xia Fan, Wang Manni, Yang Fuyao, Ma Xuelei
机构信息
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy West China School of Medicine Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Medicine (Baltimore). 2017 Sep;96(37):e8084. doi: 10.1097/MD.0000000000008084.
BACKGROUND
The maximal standard uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC) perform as new prognostic factors, but the outcomes of the published articles were inconclusive. In this meta-analysis, we evaluated the prognostic value of SUVmax, MTV, and TLG of PET/CT in patients with NPC.
METHODS
Relevant English articles were searched in PubMed and EMBASE. The data of patients and the survival outcomes were extracted. Pooled hazard ratios (HRs) were accounted to assess the prognostic value of the SUVmax, MTV, and TLG.
RESULTS
This meta-analysis combined 10 primary studies including 941 patients with NPC. The combined HRs (95% confidence interval [CI] of higher SUVmax, higher MTV, and higher TLG for event-free survival were 2.33 (95% CI, 1.39-3.91, P = .001), 2.51 (95% CI, 1.61-3.91, P < .0001), and 2.74 (95% CI, 1.91-3.93, P < .00001), respectively. Regarding overall survival, the combined HRs were 2.50 (95%CI, 1.65-3.78, P < .0001) with higher SUVmax, 3.30 (95% CI, 1.92-5.69, P < .0001) with higher MTV and 3.18 (95% CI, 1.70-5.96, P = .0003) with higher TLG.
CONCLUSION
SUVmax, MTV, and TLG were significant prognostic predictors in patients with NPC. And the results suggested that higher SUVmax, MTV, and TLG were associated with worse prognosis.
背景
正电子发射断层扫描/计算机断层扫描（PET/CT）的最大标准摄取值（SUVmax）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）在鼻咽癌（NPC）患者中作为新的预后因素，但已发表文章的结果尚无定论。在这项荟萃分析中，我们评估了PET/CT的SUVmax、MTV和TLG在NPC患者中的预后价值。
方法
在PubMed和EMBASE中检索相关英文文章。提取患者数据和生存结局。计算合并风险比（HRs）以评估SUVmax、MTV和TLG的预后价值。
结果
这项荟萃分析纳入了10项主要研究，包括941例NPC患者。无事件生存的SUVmax升高、MTV升高和TLG升高的合并HRs（95%置信区间[CI]）分别为2.33（95%CI，1.39 - 3.91，P = 0.001）、2.51（95%CI，1.61 - 3.91，P < 0.0001）和2.74（95%CI，1.91 - 3.93，P < 0.00001）。关于总生存，SUVmax升高的合并HRs为2.50（95%CI，1.65 - 3.78，P < 0.0001），MTV升高的为3.30（95%CI，1.92 - 5.69，P < 0.0001），TLG升高的为3.18（95%CI，1.70 - 5.96，P = 0.0003）。
结论
SUVmax、MTV和TLG是NPC患者重要的预后预测指标。结果表明，较高的SUVmax、MTV和TLG与较差的预后相关。
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