Kang Xin-Yao, Xu Qun-Ying, Yu Ze, Han Shu-Fang, Zhu Yu-Fang, Lv Xin
Fourth Wards of General Surgery, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch, Zhejiang.
Department of Breast Surgery, The First People's Hospital of Fuyang Hangzhou.
Medicine (Baltimore). 2020 May;99(20):e20231. doi: 10.1097/MD.0000000000020231.
To systematically evaluate the effects of physical activity on physiological markers in breast cancer survivors.
A systematic search of the PubMed, Wed of Science, Medline, CNKI and Wanfang Database was performed to identify eligible randomized controlled trials to explore physical activity on physiological markers in breast cancer survivors. STATA version 13.0 (Stata Corp LP, College Station, TX) was used for all statistical analyses.
A total of 11 articles with 941 cases were eligible in this meta-analysis. The results of the meta-analysis showed that physical activity could decrease the levels of insulin (SMD = -1.90, 95%CI: -3.2 to -0.60; I = 92.3%, P < .001), insulin-like growth factor 1 (IGF-I) (WMD = -4.67, 95%CI: -23.14 to 13.79; I = 96.2%, P < .001), insulin-like growth factor binding protein-3 (IGFBP-3) (WMD = -20.09, 95%CI: -47.15 to 6.97; I = 93.3%, P < .001). However, compared with the control group, there was not the significant change of insulin-like growth factor 2 (IGF-II), insulin-like growth factor binding protein-1 (IGFBP-1), leptin, adiponectin, glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-ɑ) levels after the intervention.
Physical activity could improve the insulin function that might be associated with decreasing the levels of IGF-I, IGFBP-3 and insulin in breast cancer survivors.
系统评价体育活动对乳腺癌幸存者生理指标的影响。
对PubMed、科学网、Medline、中国知网和万方数据库进行系统检索，以确定符合条件的随机对照试验，探讨体育活动对乳腺癌幸存者生理指标的影响。所有统计分析均使用STATA 13.0版（Stata公司，德克萨斯州大学站）。
本荟萃分析共纳入11篇文章，941例病例。荟萃分析结果显示，体育活动可降低胰岛素水平（标准化均数差 = -1.90，95%置信区间：-3.2至-0.60；I² = 92.3%，P < .001）、胰岛素样生长因子1（IGF-I）水平（加权均数差 = -4.67，95%置信区间：-23.14至13.79；I² = 96.2%，P < .001）、胰岛素样生长因子结合蛋白-3（IGFBP-3）水平（加权均数差 = -20.09，95%置信区间：-47.15至6.97；I² = 93.3%，P < .001）。然而，与对照组相比，干预后胰岛素样生长因子2（IGF-II）、胰岛素样生长因子结合蛋白-1（IGFBP-1）、瘦素、脂联素、葡萄糖、C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）和肿瘤坏死因子α（TNF-α）水平无显著变化。
体育活动可能通过降低乳腺癌幸存者的IGF-I、IGFBP-3和胰岛素水平来改善胰岛素功能。
