青蒿素对人肝癌HepG2细胞增殖和凋亡的影响：一项系统评价与Meta分析方案
Effects of artemisinin on proliferation and apoptosis of human liver cancer HepG2 cells: A protocol of systematic review and meta-analysis.
作者信息
Li Jing, Liu Zhi-Ye, Yu Hai-Bo, Xue Qing, Qu Xiu-Sheng
机构信息
Department of Physiology, Jiamusi University School of Basic Medical Sciences.
Department of Chemotherapy and Radiotherapy, First Affiliated Hospital of Jiamusi University.
出版信息
Medicine (Baltimore). 2020 May;99(20):e20290. doi: 10.1097/MD.0000000000020290.
BACKGROUND
This study will examine the effects of artemisinin on proliferation and apoptosis of human liver cancer HepG2 cells (HLCHG-2C).
METHODS
This study will systematically retrieve potential literatures in MEDLINE, Scopus, Web of Science, Cochrane Library, EMBASE, WANGFANG, and China National Knowledge Infrastructure from their initiation to the February 29, 2020. There are not limitations related to the language and publication time. All case-controlled studies (CCSs) or randomized controlled studies (RCSs) will be included in this study which investigated the effects of artemisinin on proliferation and apoptosis of HLCHG-2C. Two independent investigators will examine searched records, collect data from included studies, and will identify their methodological quality. Any divergences will be disentangled by discussion with another investigator. RevMan 5.3 software will be placed to pool the data and to carry out data analysis.
RESULTS
This study will summarize all eligible studies to test the effects of artemisinin on proliferation and apoptosis of HLCHG-2C.
CONCLUSION
The results of this study will exert evidence to examine the effects of artemisinin on proliferation and apoptosis of HLCHG-2C, and it may benefit further research, patients, and healthcare providers.
SYSTEMATIC REVIEW REGISTRATION
INPLASY202040075.
背景
本研究将探讨青蒿素对人肝癌HepG2细胞（HLCHG - 2C）增殖和凋亡的影响。
方法
本研究将系统检索MEDLINE、Scopus、科学网、考克兰图书馆、EMBASE、万方和中国知网中从建库至2020年2月29日的潜在文献。不限语言和发表时间。所有调查青蒿素对HLCHG - 2C增殖和凋亡影响的病例对照研究（CCS）或随机对照研究（RCS）都将纳入本研究。两名独立研究人员将检查检索记录，从纳入研究中收集数据，并确定其方法学质量。任何分歧将通过与另一名研究人员讨论解决。将使用RevMan 5.3软件汇总数据并进行数据分析。
结果
本研究将总结所有符合条件的研究，以检验青蒿素对HLCHG - 2C增殖和凋亡的影响。
结论
本研究结果将为考察青蒿素对HLCHG - 2C增殖和凋亡的影响提供证据，可能有益于进一步的研究、患者和医疗服务提供者。
系统评价注册
INPLASY202040075。
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